San Francisco, CA, 2 - 5 December 2019

Schedule

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Dec 212:59
Conference pass

Workshop B: Advances in adjuvant technology for vaccines

WORKSHOP B
Advances in adjuvant technology for vaccines:Vaccine adjuvants have been used successfully for decades to enhance the ability to provoke an immune response of weak antigens and improve the overall potency of vaccines. Join this workshop to explore the latest advances in novel adjuvant technology for vaccines, the value of current adjuvants and how to improve them.
Dec 213:00
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Workshop A: Uses and clinical application of immune profiling assays for cancer

WORKSHOP A
The use of novel assays and computational methods to analyse the immune system is a very fast-moving field and it is challenging to keep up with the pace of change. Join our Advances in Immune Profiling Assays workshop on 2nd December for an in depth look at the uses and clinical application of new methods to characterise and profile the human immune system for the accelerated development of new therapies.Topics:·Measuring base-line immune function ·Assessing predictive biomarkers for PD1 / PDL1 immunotherapies·How to assess the efficacy and longevity of cellular therapies·Characterising the tumor microenvironment·Discovery of genomic predictors and genomic alterations that promote or suppress immune response·Discovery and development of novel biomarkers
Dec 213:00
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Adjuvant technology and its impact on vaccine development

WORKSHOP B
Dec 213:30
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Use of receptor agonists in improving existing adjuvants or designing new novel adjuvants for different animal species

WORKSHOP B
Dec 214:00
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Precision adjuvants; tailoring immune activation for next generation vaccines

WORKSHOP B
Dec 214:30
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The cGAS-STING Pathway as a Target for Enhancing Vaccine Efficacy, Antiviral Therapeutics, and Cancer Immunotherapy

WORKSHOP B
Victor Defilippis, Associate Professor, Oregon Health and Science
Dec 215:30
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Evaluation of Human Vaccines prior Vaccination: Of Hope and Hype

WORKSHOP B

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Dec 308:30
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Immunotherapy 2020 and beyond – what are the next frontiers?

Keynotes
  • In the last 10 years ground breaking advances and progress have been made in the treatment of cancer with immunotherapy-based approaches.
  • We have seen approvals of cancer vaccines, multiple single agent and combination checkpoint inhibitor agents in a broad range of tumor types, tissue-agnostic immunotherapy and cellular and gene therapies.
  • These agents are improving survival and providing cures in some cancer patients.
  • Several new immunotherapy advancements, opportunities and challenges are on the horizon.
Dec 308:50
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Advances in integrative analysis of single cell sequencing and multiple omics data for a better understanding of response to immunotherapy and vaccination

Keynotes
  • Advances in the development of novel computational methods to understand response to therapy in infectious diseases and cancer
  • Challenges associated with large data volumes and numerous measured variables on statistical power with small sample sizes
  • Use of correlation and mechanistic connections to overcome challenges with high dimensional data
  • Important components of software platforms for data management and analysis and how they can be improved
  • Challenges of missing or incomplete data in multi-omic datasets
Dec 310:30
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Morning Networking Break

Keynotes
Meet the Investor Speed Networking: Meet, exchange interests and swap business cards with investors in the biotechnology sector. A great opportunity to maximize your time at the event and meet up to 10 investors in 15mins. Investors include:
Dec 311:30
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Dec 311:40
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Development and validation of biomarkers for diagnosis and prediction of response resistance to treatment

Immune Profiling
Dec 311:40
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Should each patient’s immune system inform their immunotherapy?

Cancer Immunotherapy
  • ATLAS™, an autologous immune assay that identifies specific immunogenic neoantigens, is more effective at identifying immunogenic CD4 AND CD8 targets than algorithms
  • High variability between patients shows that each individual’s immune system evolves differently throughout their lives
  • Immunosuppressive peptides, identified only through ATLAS, can undercut immunity and compromise immune function
Dec 311:40
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Dec 312:10
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Intralesional IL12 enhances anti-PD-1 immune response in treatment-refractory solid tumors

Immune Profiling
  • Intro
  • Plasmid DNA electroporation platform
  • KEYNOTE-695 Clinical trial highlights
  • Biomarker data
  • Conclusion
Dec 312:10
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An integrated machine-learning approach to improve the prediction of clinically relevant neoantigens

Cancer Immunotherapy
  • We will outline a high performing machine learning approach that predicts naturally presented antigens to the tumor cell surface
  • The predictor, known as the Immuneoprofiler, is integrated with several immune parameters in a deep learning layer
  • We illustrate the application of the Immuneoprofiler to significantly improve the identification of neoantigen targets for personalised cancer immunotherapy
Dec 312:10
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RosettaAntibodyDesign - a platform for computational antibody design

New Technology
Dec 312:40
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Determinants of clinical response to CAR-T therapy

Immune Profiling
Dec 312:40
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Artificial Intelligence to the rescue: towards personalized, neoantigen-targeted immunotherapeutics

Cancer Immunotherapy
Dec 312:40
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Introducing a new bioparticle platform; design, polyvalence, production and immunomodulatory potential

New Technology
Dec 312:40
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Update on the development and use of a single-dose live oral cholera vaccine

Vaccine Development
Dec 312:55
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Development of EcoCRM®, a new GMP CRM197 carrier protein

New Technology
Dec 313:10
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Networking lunch and poster session

Keynotes
Innovation & Start up Zone – meet emerging biotechs and discover their innovative platforms and novel technologies in the vaccine & immunotherapy space. Taking place in the exhibition area. Start-up companies include; Meissa Vaccines, Inflammatix, BioGraph 55, Avalia Immunotherapies
Dec 314:10
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A paradigm shift: Cancer therapy with peptide-based B-cell epitopes and peptide immunotherapeutics targeting multiple solid tumor types

Cancer Immunotherapy
  • Development of new paradigm shifting cancer immune-therapies
  • translational strategies from basic preclinical studies to clinical trials
  • detailed pipeline/ portfolio of validated B-cell peptide vaccines
  • Development of combinatorial immunotherapeutic strategies
Dec 314:10
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Targeting highly conserved influenza virus epitopes with self-assembled peptides

New Technology
  • A new vaccine platform is being developed that targets B cell epitopes derived from host and microbial proteins.
  • Peptides synthesized with epitopes from the viral M2e, neuraminidase, and hemagglutinin stem proteins induce protective antibody responses in challenged mice.
  • These results suggest a path forward for the development of a universal influenza vaccine.
Dr Chris Clegg, President, Founder and Chief Scientific Officer, TRIA Bioscience
Dec 314:10
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Development of a bioconjugate vaccine against E. coli

Vaccine Development
Dec 314:40
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Decoding cell-free biomarker patterns to optimize the next generation of precision immunotherapies

Immune Profiling
Dec 314:40
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Pfizer’s vaccine immunotherapy combination regimen for cancer

Cancer Immunotherapy
Dec 314:40
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Vaccine development in Chikungunya, a severe disease with debilitating long-term effects and global outbreak potential

New Technology
Dec 314:40
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Prophylactic and therapeutic vaccine approach targeting C. difficile infection and relapse

Vaccine Development
Dec 315:10
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Overview of Immune Epitope Database

Immune Profiling
Overview of Immune Epitope Database
  • What does the IEDB do?
  • How to access data
  • Predictive tools
  • How does this integrate into other databases?
Dec 315:10
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Mesenchymal stem cells as a novel approach for optimization of oncolytic virus delivery

Cancer Immunotherapy
Dec 315:10
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Peptide-based checkpoint receptor inhibitors as adjuvants and therapeutics in infectious diseases

New Technology
Dec 315:10
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Toxoid Based Multivalent Vaccine for Methicillin-Resistant Staphylococcus Aureus

Vaccine Development
Dec 315:40
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Susceptible or Immune? A CMV T cell assay accurately predicts patient status

Immune Profiling
  • Cellular immunity is key to controlling many viral infections, particularly in high risk populations.
  • A flow cytometry based, intracellular cytokine detection method has been developed and validated to measure CD4 and CD8 T cell responses to CMV antigen.
  • Clinical studies have demonstrated strong sensitivity, specificity, positive predictive values and negative predictive values for CMV viremia and disease.
Dec 315:40
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Increasing effectiveness of oncolytic virus therapy

Cancer Immunotherapy
Dec 315:40
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Supercharging immunotherapy with novel vector technology harnessing the exceptional immunogenicity of arenaviruses

New Technology
Dec 315:40
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Identification of novel mycobacterial factors involved in virulence and evasion of host immune responses in tuberculosis

Vaccine Development
Dec 315:55
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A novel chemistry platform for coupling immunogenic peptides to TLR2-agonist adjuvants to generate fully-synthetic, self-adjuvanting cancer vaccines

New Technology
Dec 316:40
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Induction of innate immunity against bacterial infection

Immune Profiling
Dec 316:40
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Immulytic; achieving personalized systemic neoantigen vaccination directly in the patient

Cancer Immunotherapy
Dec 316:40
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A novel hybrid virus-like-particle technology to accelerate the conversion of antigenic epitopes into efficient immunogens deliverable as vaccines

New Technology
Dec 316:40
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Dec 317:10
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Developing and utilizing positional scanning combinatorial libraries for T-lymphocyte antigen discovery

Immune Profiling
  • General concepts and illustration of positional scanning combinatorial libraries composed of trillions of peptides
  • T cell driven antigen identification approach integrates the screening results of positional scanning libraries and protein databases
  • Examples of the elucidation of the peptide and antigen specificity of T cells with unknown specificity
Dec 317:10
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Advantages of HSV-based oncolytic virus therapies for the treatment of solid tumors

Cancer Immunotherapy
Andreas Niethammer, Senior Vice President, Head of Clin Development, Immunotherapy Solid Tumors, Sorrento Therapeutics Inc
Dec 317:10
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Unique immunotherapy approach, based on an oncolytic virus non-covalently combined with tumor-specific peptides, for a highly immunogenic and rapidly adaptable tumor vaccination platform.

New Technology
Dec 317:10
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Dec 317:40
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Human in vitro modeling to inform precision vaccines for vulnerable populations

Immune Profiling
Dec 317:40
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Armed and dangerous against cancer: TGF-beta trap and personalized oncolytic adenoviruses

Cancer Immunotherapy
  • Positive clinical data from first two patients treated with personalized i.e., neoantigen enhanced oncolytic adenoviruses
  • Data from TGF-beta trap virus, which is only months away from a Phase 1 trial, that shows abscopal anticancer activity and evidence of cold-to-hot tumor transformation
  • Biodistribution data from intravenous and intratumoral administration of the TGF-beta trap virus, which demonstrates persistent non-negligible serum levels of the TGF-beta trap
Dec 317:40
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Developing multi-target single-vector vaccines and delivery devices for Venezuelan Equine Encephalitis Virus (VEEV)

New Technology
Dec 317:40
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Understanding the immunology of syphilis using modern technology to develop a vaccine against this resurgent pathogen

Vaccine Development

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Dec 408:30
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Dec 408:30
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Chairs Opening Remarks:

Engaging T-Cells, Cancer Antibodies, and Combinations
Dec 408:40
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Mucosal delivery of universal flu vaccine antigens in animal models

Vaccine Development
Dec 408:40
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Pre-clinical toxicology considerations for vaccine development

Clinical Development
Dec 408:40
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Recurrent Stage 4 Cancer: A patient’s journey and hope for the future

Engaging T-Cells, Cancer Antibodies, and Combinations
Chester Kitchen, Cancer Patient Advocate
Dec 408:40
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Opportunities and challenges for integrating delivery technologies into cancer immunotherapy

Immunotherapy Bioprocessing, Manufacture & Delivery
Dec 409:10
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Developing a single vaccine to protect against all influenza strains using ground-breaking mathematical models and research

Vaccine Development
Dec 409:10
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Novel correlates of protection against pandemic influenza

Clinical Development
Dec 409:10
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Combinations and checkpoint inhibitors; what’s working?

Engaging T-Cells, Cancer Antibodies, and Combinations
  • Landscape of combination therapies – why aren’t they working?
  • PD1 resistance – what are the major mechanisms we need to focus on?
Dec 409:10
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Development of novel antibody-directed nanotherapeutics (ADN) for infectious diseases and cancer

Immunotherapy Bioprocessing, Manufacture & Delivery
Daryl Drummond, Biotechnology Consultant
Dec 409:40
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Broader protective influenza vaccine

Vaccine Development
Dec 409:40
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The Potential Impact of a Norovirus Vaccine in the U.S.

Clinical Development
Dec 409:40
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Targeting soluble TNF to overcome trastuzumab resistance in HER2+ breast cancer

Engaging T-Cells, Cancer Antibodies, and Combinations
    MUC4 expression predicts trastuzumab resistance in HER2+ breast cancerMUC4 expression is driven by soluble TNFNeutralization of sTNF with INB03 prevents trastuzumab resistance in women with MUC4+/HER2+ breast cancer
Dec 409:40
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Engineering bispecific IgM antibodies as cancer therapeutics

Immunotherapy Bioprocessing, Manufacture & Delivery
Dec 410:10
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Protection against Respiratory Syncytial Virus (RSV) by maternal immunization

Vaccine Development
Dec 410:10
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Dec 410:10
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Versamune; a novel T-cell activating immunotherapy platform

Engaging T-Cells, Cancer Antibodies, and Combinations
Versamuneâ (R-DOTAP nanoparticles) works by facilitating several critical immunological mechanisms:
  • Superior in vivo priming of tumor antigens through dendritic cell uptake and destabilization of the endosomal membrane, enabling associated antigens to effectively access the class-I and class-II MHC pathways to prime tumor (HPV)-specific CD8+ and CD4+ T cells.
  • Potent immune activation as a result of dendritic cell maturation, induction of Type 1 interferon and critical chemokines within lymph nodes that promote T cell migration, activation and proliferation within the lymphatics.
  • Significant increase in CD8+ tumor infiltration with lowering of the Treg to CD8+ T cells ratio within the tumor microenvironment, resulting in “de-camouflaging” of tumors.
  • Induction of robust memory T cell responses resulting in protection from tumor re-challenge following treatment with R-DOTAP and HPV-E7 peptides in preclinical animal studies.
  • Systemic bioavailability of <6% associated with a lack of significant cytokine release and non-specific systemic immune activation, resulting in a highly favorable safety profile for use in combination with other I-O agents and approaches.
Dec 410:10
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Design & manufacture of next generation biotherapeutics with a scalable biochemical protein synthesis platform

Immunotherapy Bioprocessing, Manufacture & Delivery
  • Introduction to Sutro’s proprietary Cell Free Protein Expression Technology.
  • How the rapid cycle time of the CF reaction allows for high throughput screening of designed structural variants, including incorporation of non-natural amino acids, to enable development of optimal proteins for both function and manufacturability.
  • Demonstration of successful scale up from microliters at bench scale to 1000 liters in a GMP manufacturing environment.
Dec 410:25
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Using serology to support vaccine development

Clinical Development
Dec 411:30
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Interactive Roundtables - Click to View

Keynotes
Interactive discussions with like-minded peers tackling the similar challenges in vaccine, antibody and immunotherapy development (Roundtables run twice each for 45mins, select two options)
Early engagement of sites: Advantages for sponsors and CROs
Flavivirus vaccine – induced immune responses using mouse models
Managing process improvements for vaccines
Managing toxicity in combination immunotherapy
Pamela Munster, Professor, University of California San Francisco
Meet the investor: your questions answered
Strategies to improve patient stratification by interrogating the tumor microenvironment
The road map to NIH’s grant application process. How to find out more about the current programs available
Dr Susan Old, Deputy Director Of The Division Of Extramural Activities, NIAID
Dec 413:10
Conference pass

Networking Lunch and Poster session

Keynotes
Innovation & Start up Zone – hear emerging biotechs present their innovative platforms and novel technologies in the vaccine & immunotherapy space. Taking place in the exhibition area.
Dec 414:30
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A novel live attenuated RSV vaccine

Vaccine Development
Dec 414:30
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Location, Location, Location: How tissue residency influences T cell function and protective capacity

Clinical Development
Dec 414:30
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CD40 agonists to enhance antigen presentation, resulting in improved quality and magnitude of T-cell responses

Engaging T-Cells, Cancer Antibodies, and Combinations
Dec 415:00
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Next generation Pneumococcal bioconjugate vaccine, multivalent Klebsiella pneumoniae and Group B Streptococcus bioconjugate vaccine

Clinical Development
Dec 415:00
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A novel WT1-targeting multivalent heteroclitic epitope immunotherapeutic: clinical update

Engaging T-Cells, Cancer Antibodies, and Combinations
· WT1 antigen biology· Overview of galinpepimut-S technology· Updates in galinpepimut-S clinical data· Upcoming phase 3 trial
Dec 415:30
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Designing Immuno-Oncology trials to maximizing clinical outcomes and chances of success

Clinical Development
Dec 415:30
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Leveraging bispecific molecules for the combination immunotherapy of cancer

Engaging T-Cells, Cancer Antibodies, and Combinations
Dec 416:30
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A natural killer T (NKT) cell adjuvanting vaccine platform induces liver-resident memory CD8+ T cells that protect against malaria

Vaccine Development
Dec 416:30
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Developing allogeneic cancer immunotherapy with iPSC technology

Immunotherapy Bioprocessing, Manufacture & Delivery
  1. Fate is pioneering a revolutionary approach to cell therapy – we use renewable master induced pluripotent stem cell (iPSC) lines generated from ourproprietary iPSC platformto derive cell therapy product candidates that can be delivered off-the-shelf for the treatment of a large number of patients.
  2. Ourcell therapy product candidate pipelineis comprised of immuno-oncology programs, including off-the-shelf NK- and T-cell product candidates derived from master iPSC lines
  3. Discuss challenges in cell culture scale up for allogeneic cell therapies with iPSC technology
Dec 417:00
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Trial Designs for Vaccine Therapies and Personalized Medicine in Oncology

Clinical Development
Mary Redman, Associate Member, Clinical Research Division, Fred Hutchinson Cancer Research Center
Dec 417:00
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Developing Antibody-Drug-Conjugates to unique embryonic cancer stem cell targets

Engaging T-Cells, Cancer Antibodies, and Combinations
Dec 417:00
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Improving autologous CAR-T access and affordability

Immunotherapy Bioprocessing, Manufacture & Delivery
Dec 417:30
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Development of single dose vaccines for emerging and re-emerging infectious diseases, preclinical data for Ebola, Marburg, Lassa Fever and Zika as examples

Vaccine Development
Dec 417:30
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Clinical development of next generation Antibody Drug Conjugates

Engaging T-Cells, Cancer Antibodies, and Combinations
Dec 417:30
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Designing cutting edge vaccine and biotechnology manufacturing platforms

Immunotherapy Bioprocessing, Manufacture & Delivery
*topic title TBC
Charles Heffernan, Member, BioPhorum Operations Group; Director, C.R.B.

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Dec 509:10
Conference pass

Unleashing the potential of gene therapy using the non-viral UltraCAR-T platform for hematological and solid tumors

Engineered Cancer Therapies
Dec 509:10
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Development and licensure of an Ebola vaccine

Vaccine Delivery, Bioprocessing & Manufacture
Risat Jannat, Director, Global Vaccines & Biologics Commercialization,, Merck
Dec 509:40
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Advances in development of conjugate and multi-component vaccines

Vaccine Delivery, Bioprocessing & Manufacture
    The past three decades have witnessed the development and commercial licensure of several multivalent conjugate vaccines against several medically important bacterial pathogens, includingHaemophilus influenzaetype b,Streptococcus pneumoniae,Neisseria meningitidis, andSalmonella typhi. The development of these multivalent conjugate vaccines and new multicomponent candidates, currently in clinical trials, comprising additional protein antigens involves a complex strategy due to the varying structural, process and stability requirements posed by several antigens.The continued addition of more and more antigens to these multicomponent vaccines brings new challenges such as immune interference impacting vaccine efficacy.The presentation will address specific development strategies to address some of the challenges associated with advances in conjugate antigens, comprising these multivalent and multicomponent vaccines.
Dec 509:55
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Experimental human challenge models used in respiratory track diseases and malaria

Clincal Development
Dec 510:10
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A unique platform for research scale to mid-scale, host-independent biological manufacturing

Vaccine Delivery, Bioprocessing & Manufacture
Dec 510:10
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Anti-Ebola mAbs currently being used in the Ebola outbreak in DRC

Infectious Disease Antibodies
Dec 510:25
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Site’s perspective on frequent issues around vaccine trials

Clincal Development
(Title TBC)
Dec 511:10
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Targeting natural neoantigens through adoptive cellular therapies

Engineered Cancer Therapies
Dec 511:10
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Monoclonal antibody development against infectious diseases in pediatric populations

Infectious Disease Antibodies
Dec 511:40
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Drug development challenges within immune-oncology and analytical approaches to address them

Clincal Development
Dec 511:40
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Identification of novel T-cell receptor targets and specificity profiling of TCRs tested in the clinic to develop safe & effective TCR therapies

Engineered Cancer Therapies
Dec 511:40
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Challenges in vaccine manufacture in LMICs

Vaccine Delivery, Bioprocessing & Manufacture
Dec 511:40
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Antibody-based therapy to combat Staphylococcus aureus infections

Infectious Disease Antibodies
Dec 512:10
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Immuno-STAT – A novel platform for the selective modulation of antigen-specific T-cells

Engineered Cancer Therapies
Dec 512:10
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VsmAp™, Adjuvants, and VaxiPatch™ a new complete Influenza Vaccine solution that promises to improve vaccine protection, eliminate needle phobia, the cold chain and sharps waste

Vaccine Delivery, Bioprocessing & Manufacture
  • Verndari offers a completely modern influenza vaccine
  • VsmApTM, (vaccine synthetic membrane antigen presentation)
  • Advanced Adjuvants
  • VaxiPatchTM Delivery – painless and room temperature stability
  • Verndari Vaccination Kit capable of mail distribution
Dec 512:10
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Development of antibiotic drug conjugates

Infectious Disease Antibodies
Dec 512:40
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Gamma delta T-cells: A universal, off-the-shelf immune cell therapy to treat cancer and other diseases

Engineered Cancer Therapies
Dec 512:40
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Development of a versatile, single-injection vaccine formulation platform that can enhance immune response

Vaccine Delivery, Bioprocessing & Manufacture
Dec 514:20
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Microbiome and epigenetic imprinting of immune responses to vaccination in humans

Keynotes
Dec 514:50
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What will be the impact of moving towards earlier lines of therapy in cancer?

Keynotes
  • How will this change how we think about resistance?
  • What happens when we reach maximal amount of t-cell responses?
  • If immune capability decreases with subsequent lines of therapy is it a good idea to delay? Will investigational therapies preclude a patient from getting chemo?
  • Modifying the immune system to respond to immunotherapy
  • How does immunotherapy interact with radiation?
  • How will this affect drug candidate pipelines?
last published: 16/Oct/19 13:05 GMT

 
 
 

Contact us

To sponsor or exhibit contact:
Oliver Breed
+44 (0)207 092 1156

oliver.breed@terrapinn.com


To speak:
Lauren Sheppard
+44 (0)207 092 1211

lauren.sheppard@terrapinn.com