San Diego, 28 - 30 November 2018
Schedule
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Nov 2808:00
Conference pass
Nov 2808:10
Conference pass
Keynote Opening Address: The impact of vaccine legislation on public health in California
Keynotes
Nov 2808:30
Conference pass
Addressing the epidemic of misinformation
Keynotes
- What are the key drivers of hesitancy to vaccinate?
- Complacency, convenience and confidence
- What works in tackling misinformation and building trust?
- E.g. what steps are being taken to counteract sophisticated social media campaigns of parent groups?
- What responsibility do public health and education authorities have and how can companies get involved?
Nov 2809:20
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How T cells control antibody responses: T follicular helper (Tfh) CD4 T cells and germinal center B cell responses to vaccines
Keynotes
Nov 2809:45
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The evolution of antibody therapy for cancer
Keynotes
- Progress in the development of antibody drug conjugates,bispecific antibodies, and fusion protein/antibodies
- Novel approaches in antibody therapy- who is leading the next generation of antibody development?
- What have been the most successful and least successful antibody therapies? Why?
- How do we decide what level of toxicity is acceptable? Does this vary across indications?
Nov 2811:25
Conference pass
Chair’s Opening remarks
Vaccine Development
Nov 2811:25
Conference pass
Nov 2811:25
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Chair’s Opening remarks
Clinical Trials
Nov 2811:35
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Advantages of using oral tablet vaccines for protection against influenza
Vaccine Development
Nov 2811:35
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Synthetic DNA vaccines for cancer immunotherapy – Enabling personalized treatments
Immuno-Oncology
Nov 2811:35
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Designing innovative cohort adaptive sequential trials in oncology and other therapeutic areas
Clinical Trials
- How can innovative trial design help speed the development process and make it more accurate?
- Using one trial to address and identify the benefitting patient subpopulation
Nov 2812:05
Conference pass
Plant-derived VLPs as a Novel Approach to Addressing Unmet Needs in Influenza Prevention
Vaccine Development
- Advanced clinical development of a plant-derived quadrivalent VLP vaccine in adults and the elderly
Nov 2812:05
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An off-the-shelf dendritic cell vaccine candidate for treatment of CMV+ tumors
Immuno-Oncology
Nov 2812:05
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Lung- MAP: using state-of-the-art genomic profiling to match patients to the most appropriate clinical trial
Clinical Trials
- Overview of umbrella trials
- What are the advantages of using this type trial design?
- Reduction of cost, patient access, accelerated development
- Efforts to create an immunotherapy clinical trial platform within the trial design to allow for running of multiple studies at the same time.
Nov 2812:20
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Tools to identify, predict and prioritize vaccine candidates
Immuno-Oncology
- Clinical challenges in cancer immunotherapy.
- Personalized cancer vaccines have the potential to enhance the efficacy of checkpoint inhibitors but predicting them from somatic mutations is a formidable challenge
- Overview of approach to build better vaccine cocktails.
- Understand integrated genomics and cell-based solutions in the cancer immunotherapy space, including application of whole transcriptome analysis to characterize the tumor microenvironment and biomarker discovery approaches to predict patient response.
Nov 2812:35
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Panel: How will we integrate knowledge gained from the UIVI and other research into the development of a Universal Influenza Vaccine?
Vaccine Development
Nov 2812:35
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Use of peptide antigens in immune-oncology vaccines and T-cell therapeutics
Immuno-Oncology
Nov 2812:35
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Understanding which patients are most likely to responds using precision medicine tools – using MSI as a biomarker
Clinical Trials
Nov 2812:50
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Leveraging the advantages of viral recognition as a cancer immunotherapy
Immuno-Oncology
- Immunomic is addressing the challenges in I-O by applying our proven UNITE technology platform
- LAMP-based nucleic acid immunotherapies have the potential to broaden the current use of cancer immunotherapy by complementing approved and investigational approaches.
- LAMP-based nucleic acid immunotherapy has potential as cancer immunotherapy in two general ways:
- Activation of the immune system against highly immunogenic tumor types, potentially amplifying the response seen with checkpoint inhibitors
- Creation of a new, robust immune response to tumor types that don’t otherwise provoke an immune reaction, by reconfiguring a critical component of our immune system
- Several discovery stage programs for virally driven cancers including MCC, NPC/Gastric and HCC. INDs to be filed for these programs in 2019.
Nov 2813:05
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Personalized immunotherapy gambit
Clinical Trials
Nov 2814:00
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Lunchtime presentation & book signing: “Vaccines did not cause Rachel’s Autism”
Keynotes
Nov 2814:50
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A live attenuated pertussis vaccine to prevent disease, colonization and transmission
Vaccine Development
- Why we need aB. pertussisvaccine that induces potentmucosal immunity
- Relationship between colonizing nasopharyngeal infection and disease
- Mechanism of action for a live attenuated intranasal vaccine
- Non-human primate challenge model data
- Clinical study results
Nov 2814:50
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Next generation platform for the development of personalized synthetic cancer vaccines
Immuno-Oncology
- Development of vaccine platform from concept to delivery
- Bioinformatic immunogen design, use of long peptides and heat shock proteins
- Challenges of working with peptides
- Selecting the correct mutations in each patient
- Parallel approach to selecting neoantigens represented by abnormal post-translational modifications
- Potential for combination therapy
Nov 2814:50
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Clinical trials in immune-oncology – What endpoints should we prioritize in different stages of development?
Clinical Trials
Nov 2815:20
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Pertussis and Pertussis vaccines; mistakes made during a 112 year odyssey and what some of those mistakes bode for the future
Vaccine Development
- During the 20th century, B. pertussis was extensively studied in animal model systems and many “toxins” and protective antigens were described.
- DTaP vaccines were developed and put into general use in the USA in 1997.
- During the last 13 years, major pertussis epidemics have occurred in the USA due to deficiencies in DTaP vaccines.
- Two of the deficiencies are the small number of antigens and the type of cellular immune response.
- The small number of antigens leads to linked-epitope suppression.
- Because of linked-epitope suppression, all children who were primed by DTaP vaccines will be more susceptible to pertussis throughout their lifetimes.
Nov 2815:20
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Overcoming tumor immune suppression using a novel retroviral replicating vector
Immuno-Oncology
- Pre-clinical data: observations to support immune mediated mechanism of action
- Phase 1 data in recurrent high-grade glioma: durable complete responses seen in dose escalation studies
- Clinical Development: Food and Drug Administration Breakthrough Therapy Designation, European Medicines Agency’s PRIME designation and Phase 3 trial in recurrent glioblastoma and anaplastic astrocytoma
- Updates in studies for solid tumors
Nov 2815:20
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Clinical development of infectious disease vaccines using measles-based vector platform and application to immuno-oncology
Clinical Trials
Nov 2815:50
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Updates in the clinical development of a chikungunya vaccine
Vaccine Development
- Trends in chikungunya epidemiology
- VLP vaccine technology
- Updates in phase 2 clinical trials
Nov 2815:50
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The next wave: development of BCMA CAR-T therapies for multiple myeloma
Immuno-Oncology
Nov 2815:50
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Getting Closer to the Market: BiondVax's Universal Flu Vaccine Pivotal Phase 3 Trial
Clinical Trials
- M-001 technology
- Phase 3 trial protocol
- Plans for getting to the market
Nov 2816:50
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Progress towards licensure and deployment of a malaria vaccine
Vaccine Development
Nov 2816:50
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Creation of off-the-shelf TCR-less CAR T cell therapies
Immuno-Oncology
Nov 2816:50
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Updates of VRCs Zika Vaccine Trials
Clinical Trials
Nov 2817:20
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Panel: Is there a future for arbovirus vaccines?
Vaccine Development
- What is the current landscape for dengue, zika and other arbovirus vaccines?
- Which other arboviruses should be prioritized for vaccine development or for improvements of the existing vaccine(s)?
- What might emerging arboviruses look like and what improvements are needed in current vaccines?
- Finding a better way to evaluate these vaccines before going into phase 3 trials.
- Using human protection models to discover the keys to eliciting a protective immune response
- How will the immune response to one virus affect that of another?
- What are the challenges to funding and commercializing arbovirus vaccines?
Nov 2817:20
Conference pass
Strategies for the development of safer and more effective CAR-T therapies
Immuno-Oncology
- General strategies for CAR-T cell control
- Defining small molecule vs antibody-based targeting – why we use Ab-based targeting.
- Deep dive into the technicalities of designing these switches to control different targets
- Universality of the platform and potential for use in solid tumors.
Nov 2817:20
Conference pass
A year of substantial progress: clinical development of TB vaccine candidates
Clinical Trials
- A TB vaccine is urgently needed to meet the WHO and UN goals for ending TB
- Update on status of the overall pipeline of TB vaccine candidates
- Substantial progress was demonstrated by the results of two efficacy trials of vaccine candidates
- Implications of the efficacy trial results and takeaways for future candidates and trials
Nov 2817:50
Conference pass
Allogenic vs autologous CAR-T therapies – pros and cons
Immuno-Oncology
Nov 2817:50
Conference pass
Clinical development of a subunit based congenital CMV vaccine
Clinical Trials
- Vaccine development for CMV: High unmet medical need
- CMV vaccine development at GSK, past and present
- Critical challenges facing CMV vaccine developers
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Nov 2908:30
Conference pass
Chair’s Opening remarks
Vaccine Development
Nov 2908:30
Conference pass
Chair’s Opening remarks
Immuno-Oncology
Nov 2908:30
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Chair’s Opening remarks
Delivery, Bioprocessing & Manufacturing
Nov 2908:40
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CEPI Vaccine Portfolio overview
Vaccine Development
Nov 2908:40
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Clinical development of a multi-mechanistic next generation innate immune checkpoint inhibitor that targets CD47
Immuno-Oncology
Nov 2908:40
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Challenges of glycoprotein vaccines; the link between process design and antigenicity profiles
Delivery, Bioprocessing & Manufacturing
Nov 2908:55
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Advantages of the TriGrid delivery system for delivery of DNA vaccines
Delivery, Bioprocessing & Manufacturing
Nov 2909:10
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A novel approach to developing single dose and safe vaccines for emerging infectious diseases
Vaccine Development
- In vivo production of VLPs allows them to be more readily recognized by the immune system
- Safety and durability of vaccines demonstrated in HIV clinical trials
- Platform can be applied to multiple vaccine targets including; Ebola, Zika and Lassa
- Differs from other platforms as there is no need for adjuvants and is thermally and genetically stable
Nov 2909:10
Conference pass
Immunotherapy in cancer - combinations are key
Immuno-Oncology
Nov 2909:10
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Expanding Vaccine Effectiveness with Needle-Free Delivery
Delivery, Bioprocessing & Manufacturing
- Commercially available Needle-free delivery systems
- Established clinical efficacy with commercial vaccines
- Helping Nucleic Acid based vaccines toward licensure
Nov 2909:40
Conference pass
Development of a replicating viral-vector based Lassa vaccine candidate
Vaccine Development
Nov 2909:40
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From neoantigen conjugates, to plasmid DNA vaccines, rapid response in small scale production towards personalized medicine
Delivery, Bioprocessing & Manufacturing
Nov 2911:30
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Challenges for next generation adjuvants
Keynotes
Nov 2911:30
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Considerations for successful cancer immunotherapy in aged hosts
Keynotes
Nov 2911:30
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Development of predictive biomarkers to determine optimal combinations in precision immunotherapy
Keynotes
Nov 2911:30
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How can we improve speed, delivery and cost of next generation cancer vaccines?
Keynotes
Nov 2911:30
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Legal considerations for partnering with government bodies, pharma and biotechs
Keynotes
Nov 2911:30
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New approaches for assessing T-Cell responses to vaccination
Keynotes
Nov 2911:30
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Oncolytic virus strategies; Development personalized oncolytic viral vaccines
Keynotes
Nov 2911:30
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Prospects and challenges for development of a Group A Streptococcal Vaccine
Keynotes
Nov 2911:30
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Surveillance systems to comprehensively monitor the use and safety of vaccines during pregnancy
Keynotes
Nov 2911:30
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What are investors looking for in emerging biotechs?
Keynotes
Nov 2911:30
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What are the next steps when immunotherapy trials fail after receiving accelerated approval?
Keynotes
Nov 2911:30
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What are we doing to target potential responders or enrich for potential responders in immuno-oncology?
Keynotes
Nov 2914:10
Conference pass
Human challenge studies for universal influenza monoclonal antibodies
Vaccine Development
Nov 2914:10
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Early clinical development of antibody drug conjugates: challenges and opportunities
Immuno-Oncology
Nov 2914:10
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A DNA vaccine platform to rapidly produce countermeasures against emerging viral threats
Delivery, Bioprocessing & Manufacturing
- Describe a highly scalable manufacturing process for the rapid production of DNA-based vaccines for emerging infectious diseases
- Discuss the stability profile of our DNA-based product
- Offer a real-life example of a rapid response to an infectious disease – Zika
Nov 2914:40
Conference pass
Development of trispecific antibodies for the treatment of HIV and potential for application to other infectious diseases
Vaccine Development
- Background on broadly neutralizing antibodies to HIV addressing potency and breadth of coverage
- Potential for combinations of antibodies to provide optimum coverage for therapy or prevention of HIV infection
- Pre-clinical development and testing of a trispecific anti-HIV antibody molecule
- Update on clinical development and testing of a trispecific anti-HIV antibody molecule
Nov 2914:40
Conference pass
Cell free protein synthesis and site-specific conjugation platforms for the development of ADCs and other antibody-based therapies: Focus on STRO-001 and STRO-002
Immuno-Oncology
Nov 2914:40
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Pharmaceutical development and manufacturing strategies for delivering highly personalized cancer vaccines to patients
Delivery, Bioprocessing & Manufacturing
Nov 2915:10
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Development of monoclonal antibodies against Ebola and other filoviruses
Vaccine Development
Nov 2915:10
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Bispecific Technology for Multiple Avenues of T-cell Activation
Immuno-Oncology
- Checkpoint bispecifics to improve therapeutic index: PD1 x CTLA4
- Triple checkpoint blockade: LAG3 x CTLA4 bispecific plus anti-PD1
- Checkpoint plus costim.: PD1 x ICOS
- Potency-tuned IL15 for prolonged T cell stimulation
Nov 2915:10
Conference pass
Meeting the demand: Why continued innovation in immunotherapy manufacturing is crucial
Delivery, Bioprocessing & Manufacturing
Nov 2916:10
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Harnessing Natural Immunity to Create Breakthrough Therapies for Infectious Diseases
Vaccine Development
- These antibodies are isolated from individuals with natural immunity against pathogens.
- Antibody sequences are derived from unmodified heavy and light chain human B lymphocyte sequences that have undergone ontogeny and selection inside a human body.
- Antibodies derived as a result of a human immune response are expected to exhibit high affinity, ideal safety and pharmacokinetics.
- XBiotech’s discovery and production technologies help bring these novel therapeutics from bench to bedside in a relatively short timeframe
Nov 2916:10
Conference pass
Bispecific therapies as monotherapies and in combination with checkpoint inhibitors
Immuno-Oncology
Dr Maria Karasarides, Executive Director, ImmunoOncology, Regeneron Pharmaceuticals
Nov 2916:10
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Advances in technology and ongoing challenges in the development of next generation antibody therapeutics
Delivery, Bioprocessing & Manufacturing
- Overview of status of bispecific research – advantages of bispecific therapies vs two monotherapies
- Alternative scaffolds for bispecific antibodies
- Manufacturing strategies and challenges – production, engineering and stability
Nov 2916:40
Conference pass
Development of a broadly neutralizing monoclonal antibody with extended half-life technology for the prevention of RSV in all infants
Vaccine Development
- Overview of early discovery work
- Updates from 2 completed clinical trials
- New work on International Network for Optimal Resistance Monitoring (INFORM) RSV in collaboration with ReSViNET
Nov 2916:40
Conference pass
Biologic and clinical activity of first in class ICOS agonist antibody in combination with checkpoint inhibitors
Immuno-Oncology
- Preclinical rationale for development of JTX-2011, an ICOS agonist
- Rationale for combinations with PD-1 inhibitors, CTLA-4 inhibitors, and vaccines
- Clinical and biomarker data for JTX-2011 in patients with advanced solid tumors that supports further development
Nov 2916:40
Conference pass
Development of active immunoprophylaxis with DNA-encoded monoclonal antibodies (dMAb)
Delivery, Bioprocessing & Manufacturing
Nov 2917:10
Conference pass
Immune Dampening and Refocusing for deriving novel biologics for difficult and unmet infectious disease and oncology applications
Vaccine Development
- Addressing the problem of evolved immunodominance in antigenic structures
- What is deceptive Imprinting and how does it work?
- e.g. what is its evolutionary benefit?
- What are the immuno-chemical-physical characteristics that drive it?
- e.g. how can these be identified today and tomorrow?
- What processes and technologies are available to overcome this evolved pathogen survival strategy?
- Review Immune refocusing technology
Nov 2917:10
Conference pass
Clinical evaluation of a fully human monoclonal antibody for the treatment and diagnosis of CA19-9 positive malignancies
Immuno-Oncology
Nov 2917:10
Conference pass
Rapid discovery of rare B-cells and manufacturing of mAbs with MabIGX technology
Delivery, Bioprocessing & Manufacturing
- Application of nano-culture arrays to comprehensively screen the B-cell repertoire from convalescent patients for rare, functionally optimized B-cells
- Immortalization and stabilization of selected B-cell using engineered fusion partner cell line to obviate the need for recombinant mAb expression from conventional mAb production cell lines
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Nov 3009:00
Conference pass
Chair’s Opening remarks
Vaccine Development
Nov 3009:00
Conference pass
Chair’s Opening remarks
Immuno-Oncology
Nov 3009:00
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Chair’s Opening remarks
Funding & Partnerships
Nov 3009:10
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Predicting vaccine responses in the very young & old
Vaccine Development
Nov 3009:10
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Single cell functionality serves as a predictive biomarker for overall survival of pancreatic cancer patients treated with GVAX vaccine
Immuno-Oncology
- Polyfunctional Strength – the secretion of two more cytokines per cell, where the cytokine secretion intensity is tied to the cell which produced it, is a more accurate predictor of clinical outcome than flow cytometry, bulk protein analysis or gene array.
- Single Cell Functionality has correlated with Objective Response across IO: CAR-T, Checkpoint Inhibitors and Cancer Vaccines
- Polyfunctionality of CD4+ T-cells is a predictor of Overall Survival of patients treated with the GVAX Vaccine where post- versus pre-vaccination fold-change of the polyfunctional strength index was associated with patient overall survival (P = 0.001).
Nov 3009:10
Conference pass
Panel: How federal labs bring value to your company’s pipeline and bottom Line
Funding & Partnerships
- What are federal labs looking for when partnering with biotech and pharma companies?
- What are the current areas of interest?
- What do you need to know about IP and future partnerships?
Nov 3009:40
Conference pass
FluoroSpot analysis of immune memory against malaria vaccine candidate antigens
Vaccine Development
- Benefits and possibilities of the FluoroSpot assay in vaccine research
- Studying the kinetics of malaria-specific B-cells after infection
- Analysis of B cell cross-reactivity against polymorphic malaria antigen MSP-2
- What the future might hold for the FluoroSpot assay
Nov 3009:40
Conference pass
An integrated machine-learning approach for improved prediction of clinically relevant neoantigens
Immuno-Oncology
- Current neoantigen discovery algorithms are not optimal to predict presentation to the cell surface.
- Here, we outline a high-performing machine learning approach, trained on mass-spectrometry data, that predicts naturally processed and presented antigens.
- The predictor is integrated with several immune parameters, such as HLA binding, in a deep learning layer to predict bone fide neoantigens.
- We illustrate its application to significantly improve the identification of neoantigen targets for personalized cancer immunotherapy
Nov 3009:55
Conference pass
Identification of novel mycobacterial factors involved in virulence and evasion of host immune responses in tuberculosis
Vaccine Development
Nov 3010:10
Conference pass
Investigating the effects of age and immunosenescence on influenza and vaccine-induced immunity
Vaccine Development
Nov 3010:10
Conference pass
A Rational Systematic Approach to Find Combinations of Pharmacologic and Immune Therapies that Target Identifiable Oncogenic States
Immuno-Oncology
- Defining oncogenic states
- Selecting 5-10 oncogenic states and identifying state-specific immunological targets, including immune checkpoints, neoantigens/anti-tumor epitopes, antibodies, and chimeric antigen receptors
- Developing a multifactorial predictive model for eachoncogenic state to identify the most effective combinations
- Validation of these perturbagens in isogenic cell systems, cancer cell lines, genetically engineered mouse models, and patient-derived xenografts
- Insight into the development of novel treatment strategies
Nov 3010:10
Conference pass
Growing your company into a market leading organization
Funding & Partnerships
Nov 3011:39
Conference pass
New Technology Showcase:
Funding & Partnerships
- Present your solutions to a panel of seasoned investors for expert advice on how to catapult your business to the next levelInvestors:
Nov 3011:40
Conference pass
The impact of immune experience on responses to infection and vaccination
Vaccine Development
- Microbial experience alters the mouse immune system to more closely reflect the human immune system in a number of important ways
- With microbial experience, the T cell pool is largely represented by cells of an effector/memory phenotype
- Increasing immune experience confers a protective advantage against some infections, but not others
- T cell directed vaccines or 'weak' priming methods are less effective after immune experience
Nov 3011:40
Conference pass
A mechanistic understanding of the generation and regulation of T cell responses can inform superior vaccine development
Immuno-Oncology
Nov 3011:40
Conference pass
Technology Showcase 1: Supercharging immunotherapy targeting infectious disease & cancer
Funding & Partnerships
Nov 3011:55
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Technology Showcase 2: Therapeutic antibodies for neurodegenerative tauopathies
Funding & Partnerships
Nov 3012:10
Conference pass
Using predictive models to interrogate human immunity
Vaccine Development
Nov 3012:10
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Panel: Integrating our understanding of the tumor microenvironment and the microbiome to inform the development of I-O treatment
Immuno-Oncology
- Our current understanding the biology of the tumor microenvironment and microbiome in cancer.
- How can we apply this to the development of novel immunotherapies?
- Examples of data sharing efforts and industry/ academic collaborations
Moderator: Dr Maria Karasarides, Executive Director, ImmunoOncology, Regeneron Pharmaceuticals
Nov 3012:10
Conference pass
Technology Showcase 3: A Novel VLP-Based HBV Immunotherapy to Achieve Viral Clearance Of Chronic Infection
Funding & Partnerships
Nov 3012:25
Conference pass
Technology Showcase 4: Immunotherapy-based eradication of established tumors with a systemically administered multiple Toll-like receptor agonist
Funding & Partnerships
Nov 3012:40
Conference pass
Viral changes and antibody features that could provide a possible template for vaccine design
Vaccine Development
Nov 3012:40
Conference pass
Technology Showcase 5: Leveraging the gut microbiome for the treatment of cancer
Funding & Partnerships
Nov 3012:55
Conference pass
Technology Showcase 6: Microscopic imaging of epigenetic landscape for drug discovery
Funding & Partnerships
Dr Alexey Terskikh, Co-Founder, Stelvio Oncology
Nov 3014:10
Conference pass
Chair’s Opening remarks
Keynotes
Nov 3014:20
Conference pass
Accelerating progress of precision immunotherapy from laboratory to clinic through strategic collaborations
Keynotes
- Progress through research, clinical trials and genomic analysis
- Will these projects lead to us grouping cancers differently, e.g. according to genetic faults?
- How are we working together to integrate this work and ensure we make therapies available to patients rapidly?
Nov 3015:20
Conference pass
Leveraging the power of AI & machine learning for accelerated vaccine & immunotherapy development
Keynotes
- Applications of machine learning and predictive modeling
- Using machine learning techniques to decipher the human microbiome
- The increasing complexity of genomic data
- How can we translate the success seen in precision medicine to chronic diseases?
- Connecting deep phenotyping to genetics
- Examples of collaborations and exciting new technologies.
Dr Larry Smarr, Founding Director, Calit2
last published: 22/Nov/18 11:45 GMT
Contact us
To sponsor or exhibit contact:
Oliver Breed
+44 (0)207 092 1156
oliver.breed@terrapinn.com
To speak:
Lauren Sheppard
+44 (0)207 092 1211
lauren.sheppard@terrapinn.com
Organiser
