Ales Strancar | MD
Sartorius BIA Seperations
Aleš Štrancar has been the Managing Director of Sartorius BIA Separations since its founding in 1998. He is a key inventor of the CIM Convective Interaction Media® monolithic columns technology and has co-invented numerous analytical methods for pDNA, mRNA, AAV, Adeno, and other viruses. Aleš has co-developed several DSP processes, including pDNA for Boehringer Ingelheim and AAV for AveXis/Novartis. He is the author or co-author of over 100 scientific papers on separation and purification technologies and holds several granted patents.
Appearances:
Day 2 - Wednesday 29 October @ 13:45
Manufacturing of LNPs with multiple nucleic acids payloads and surface “decoration”
-LNPs with multiple payloads and proteins on the surface are very heterogenous, chromatography approach is required to purify the product.
-Replacing the TFF with OH chromatography improves the product recovery.
-To define the product and to enable the batch-to-batch product manufacturing consistency new analytical methods to characterise the LNP were developed.
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