ANNETTE BAKKER, Ph.D., CEO — CHILDREN’S TUMOR FOUNDATION (CTF), Chair (ad interim) of CTF Europe Annette Bakker, a Ph.D. in Biochemistry, was an academic researcher for ten years - University Antwerp, Yale Medical School, and the Myology Institute Paris. Following this, she accumulated 15 years of experience in multiple executive leadership positions in Oncology R&D in big pharma and biotech. She holds over 50 publications and 5 patents (https://orcid.org/0000-0001-8420-7831). Motivated by the realization that numerous groundbreaking discoveries fail to translate into clinical benefit, she joined the Children’s Tumor Foundation (CTF) in 2011 to deploy CTF's talent, time, and treasure (TTT) to help bridge the gaps between scientific discoveries and clinical benefits, particularly focusing on neurofibromatosis, a rare genetic disorder. In 2022, she was decorated Officer in the Order of Leopold by the king of Belgium for her bold approach and dedication to improving patients' lives. Annette strongly believes that patient-centric research foundations hold a unique position in the R&D ecosystem. Organizations, such as CTF, are trusted partners for all stakeholders, with the same sense of urgency as the patients. As FasterCures Changemaker and Chan Zuckerberg Initiative mentor, Annette is deeply committed to constructing an enterprise that not only benefits patients with NF but serves as a model for expediting drug discovery and development within the broader rare disease community.
The pharmaceutical and biotech sectors allocate billions of dollars annually to developing new therapies. However, some assets face discontinuation not due to scientific or medical reasons but due to marketing and strategic priorities. These 'shelved assets' frequently remain underutilized despite their potential medical and commercial value.
This panel brings together Freda Lewis-Hall, former Chief Medical Officer at Pfizer and a renowned expert in drug repositioning, Andrew Lo, an MIT finance professor specializing in innovative financial models. Moderated by Annette Bakker, CEO of the Children's Tumor Foundation and a firm advocate for releasing shelved assets for NF, the discussion will focus on crafting frameworks that align medical needs with economic incentives. Together, the panel will present opportunities to transform overlooked assets into lifesaving treatments for patients with low-incidence or low-market diseases.
By addressing this pressing issue, the panel will spotlight actionable solutions to create a win-win scenario—improving healthcare outcomes while driving economic growth in the pharmaceutical and biotech industries globally.