E9 Genomics

Startup

E9 Genomics builds scientific reasoning systems that help therapeutics teams systematically explore biological search spaces to uncover non-obvious, high-value opportunities hidden outside the center of the distribution.

Founded by the team behind gnomAD, we combine large-scale biological data infrastructure, agentic search, and structured scientific reasoning to help organizations make better decisions in areas where evidence is sparse, biology is complex, and the cost of missing the right answer is high.

Our work began in rare disease, where overlooked opportunities can create outsized patient impact. Using Urchin, our biological reasoning and decision-support platform, we help teams identify and prioritize non-obvious therapeutic opportunities by integrating genetics, molecular biology, literature, translational evidence, and proprietary datasets into a unified reasoning workflow.

In one recent drug repurposing engagement for CMT1A, Urchin analyzed proprietary RNA sequencing data from mouse models, identified key pathways, nominated compounds, surfaced drug classes scientific advisors had not previously considered, and designed dosing schedules for the 15 compounds now advancing to *in vivo* testing.

Today, we partner with therapeutics teams across indication selection, drug repurposing, target and program prioritization, and other high-stakes R&D decisions where finding the overlooked opportunity matters.

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