Melissa Ronan | Senior Manager, PRISM Screening
Broad Institute
Melissa Ronan is a biotechnology leader with over 15 years of experience advancing laboratory automation, high-throughput screening, and drug discovery. During her eight years at the Broad Institute of MIT and Harvard, she has led cross-functional teams developing automated workflows and software tools that power large-scale drug screening using the innovative PRISM platform for cancer research. Previously, she spent a decade at Chromocell Corporation, where she worked at the intersection of automated laboratory methods and high-throughput assay development. Melissa is passionate about combining automation, AI, and data-driven workflows to accelerate R&D innovation and help scientists focus on discovery rather than repetitive processes.
Appearances:
Day 2: 29th October @ 12:00
Scaling data generation and instrumentation in a connected automated lab
The PRISM platform (Broad Institute) is a unique multiplexed cell viability screening approach, which utilizes DNA barcodes in cancer cell lines so that up to 1,000 lines can be screened together in a single assay. You'll see how the PRISM lab generates sensitivity profiles from viability and baseline genomic data, contributes to public resources like the Dependency Map, and is working toward a fully autonomous, week-long walk-away assay. Using an integrated system, we run our entire cell viability assay (drug plating, cell treatment, DNA extraction, and sequencing library prep) in one automated workflow, reducing manual touch points and enabling automatic sample tracking via an in-house LIMS and connected databases to support rapid drug discovery at scale
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