Karthik Siram | Senior Scientist
university of montana

Karthik Siram, Ph.D., is a formulation scientist specializing in the design and translation of 
advanced vaccine adjuvant systems. He earned his doctorate in Pharmaceutics, focusing on the 
design of nanoparticles for lymphatic targeting. As a Senior Scientist at the Center for Translational 
Medicine at the University of Montana, he discovers, develops, and scales up next-generation 
vaccine adjuvant formulations from early discovery through GMP manufacturing, and contributes 
to IND-enabling activities. His experience includes developing and optimizing scalable 
formulation techniques, writing SOPs, navigating CMC workflows, troubleshooting API and 
formulation instabilities, and implementing quality-driven processes suitable for regulatory 
submission. Dr. Siram has spearheaded formulation design, process development, technology 
transfer, and CDMO coordination for multiple GMP manufacturing campaigns, notably supporting 
the advancement of multiple small-molecule adjuvant formulation platforms to Phase 1 clinical 
readiness for opioid and influenza vaccine programs.