Aurelie Mallinger | Laboratory Leader
Bayer

Aurélie Mallinger received her PhD in organic chemistry in 2008, under the supervision of Dr. Charles Mioskowski and Dr. Thierry Le Gall in France, where she focused on natural product synthesis. In 2009, she undertook a one-year postdoctoral fellowship at the University of Oxford with Prof. Jeremy Robertson. From 2010 to 2017, Aurélie worked as a lead medicinal chemist at the Institute of Cancer Research (ICR) in London, contributing to multidisciplinary drug discovery projects for the treatment of cancer in close collaboration with Merck KGaA. In 2017, she moved to Germany to work with Phenex Pharmaceutical. Since 2019, Aurélie has been working at Bayer in Lyon as a laboratory and project leader in crop science.

Appearances:

Day 1: 27th May @ 14:30

A novel tool for accelerating SAR analysis and reporting, to enhance compound design

Analysis is an essential component of the DMTA cycle. Indeed, Structure Activity Relationships analysis (SAR) is a key source of inspiration for compound design. However, SAR analysis is a very time-consuming process, impeding the frequency of regular updates. Moreover, the evolving context demands the consideration and analysis of an increasing array of parameters to design effective and sustainable plant protection products. To address these challenges, Bayer initiated a collaboration with Discngine to develop a new tool to accelerate SAR analysis and reporting across multiple endpoints. The ultimate goal is to support, guide and improve decision making in projects both in terms of quality and efficiency. The tool contains several modules enabling the creation of SAR overviews in a fully streamlined manner and facilitate in-depth analysis of Matched Molecular Pairs (MMP) and R-Group deconvolution reports. We will present the rational to engage into the development of this tool, provide an overview highlighting its capabilities and its potential to significantly facilitate SAR analysis and impact on compound design. Lastly, we will discuss our extended collaboration with Discngine and the productization of one of our SAR reporting module, now available for commercial use as a Discngine solution, ‘SAR Slides’.

Aurelie Mallinger, Laboratory Leader, Bayer

David Bernier, Scientist / Molecular Designer, Bayer S.A.S.