Matteo Samuele Pizzuto | Director of Research, Department of Antibody Discovery and Engineering
Vir Biotechnology

Festival of Biologics Day 2 @ 11:50

PRO-XTEN™ Masked T Cell Engagers: Protease-activated TCEs for Tumor-specific Targeting

·       PRO-XTEN™ expands the therapeutic index of T-cell engagers through tumor-selective activation and conditional pharmacokinetics.

·       Rapid and flexible discovery workflows enable efficient selection of optimized anti-TAA binders with favorable functional and developability profiles.

·       The platform is designed to maximize efficacy while minimizing systemic toxicity through robust masking and controlled activation.

·       Preclinical data underscore the translational potential of the platform, which is currently being evaluated in clinical programs.

Matteo Samuele Pizzuto, Director of Research, Department of Antibody Discovery and Engineering, Vir Biotechnology

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Matteo Samuele Pizzuto / PRO-XTEN™ Masked T Cell Engagers: Protease-activated TCEs for Tumor-specific Targeting

Matteo Samuele Pizzuto, Director of Research, Department of Antibody Discovery and Engineering,
Vir Biotechnology

Matteo Samuele Pizzuto, PhD, is Director of Research in the Department of Antibody Discovery and Engineering at Vir Biotechnology, where he leads discovery projects spanning immuno-oncology and infectious diseases. Based in Bellinzona, Switzerland, he oversees multidisciplinary teams advancing...

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