Mario Pereira | Director of Technology and Business Development.
ATUM
Mario Pereira, PhD, is the Director of Technology and Business Development at ATUM, where he leverages over 15 years of academic and industrial expertise in recombinant protein expression. Mario earned his PhD in Biotechnology from the University of Manchester, specializing in the transcriptional mechanisms and genomic environments of CHO cells. Before joining ATUM, he held several roles at Horizon Discovery from Senior Scientist, to Strategic Account Manager and served as a Principal Scientist at FUJIFILM Diosynth Biotechnologies. Throughout his career, Mario has remained dedicated to bridging the gap between scientific discovery and biotherapeutic manufacturing, driving the development of impactful technologies that advance the industry.
Appearances:
Festival of Biologics Day 2 @ 11:50
Overcoming Manufacturing Bottlenecks in Multispecific Design via Native Scaffold Engineering
The landscape of modern protein engineering allows for unprecedented multi-affinity designs, yet geometric complexity often comes at the cost of developability, manufacturing bottlenecks, and unpredictable in vivo mechanisms. To address these liabilities, we leveraged our years of bispecific development experience to design a novel solution that minimizes mutations while still enabling correct assembly. By retaining the structural integrity of the native IgG scaffold, this approach supports heavy-chain heterodimerization and correct light-chain pairing without compromising expression titers or stability. This presentation details the mechanism of our Lock-In platform, demonstrating how it serves as a robust, plug-and-play foundation for the predictable and scalable production of complex multispecific therapeutics.
Created by
Terrapinn is proud to be a member of isla.
Working together to build sustainable events