Mariana Hugo Borges Barreto Silva | Postdoctoral Fellow
University of Ghent
Mariana Hugo Silva is a Postdoctoral Researcher at Ghent University, working closely with Pfizer to provide mechanistic insights into mRNA-LNP vaccines. She earned her PhD from the University of Limerick, Ireland, conducting research across academic and industry settings including Johnson & Johnson and Trinity College Dublin. Her doctoral work focused on developing innovative long-acting injectable formulations for small molecules, aimed at improving patient adherence through controlled drug release. With a strong foundation in formulation science and industry experience, Mariana’s current research advances understanding of large-molecule delivery systems in biopharma.
Appearances:
Festival of Biologics Day 3 @ 12:20
How LNPs Change Under Stress: Analytical Insights for Translational mRNA Medicine
- Antibody Engineering using Machine Learning assisted Yeast Surface Display enables affinity maturation of an immune checkpoint blocker with low sequence intrusiveness.
- Deep Learning models are trained on context specific biological data to infer new variants not observed by sequencing and accurately predict their properties.
- in vitro antigen binding and in vivo therapeutic assessments confirms the efficacy of the approach.
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