Ian has over 10 years of experience in downstream processing, with expertise spanning process development in a startup environment, customer‑facing project leadership within CDMOs, and development and GMP operations in large pharmaceutical companies. He particularly enjoys working with non‑traditional antibody molecules, using Ecolab HipH and CH1 chromatography resins to solve complex purification challenges.
A new wave of monoclonal antibody therapeutics is in development that utilize complex molecular structures as a route to enhanced efficacy. These challenging molecules require new synthetic pathways for their creation, pathways that present unique purification challenges which must be overcome for commercial viability. Increasingly, the choice of affinity resin in the purification workflow is critical to obtaining viable results that can be scaled to commercial volumes. This presentation describes how the unique features of modern affinity resins can be leveraged to create robust purification workflows for even the most challenging molecules.