Arnout Van Hyfte | Vice President of Product Management
Mindwalk

BioTechX EU Day 1 @ 16:50

Beyond the AI Model: How Context Layers Help Shape Agentic AI in Drug Discovery

In agentic AI for drug discovery, the model is only as useful as the biological context it can access, connect, and reason over. ETL pipelines and ELN/LIMS repositories store and organize records, but they are not designed to fully represent biology: data joins can remain syntactic, retrieval may rely on text similarity, and functional relationships, cross-modal linkage, reasoning provenance, and negative-result memory can remain fragmented. The data can sit static, and relations and semantics can stay incomplete. ReefIQ™, powered by HYFT® Technology, is MindWalk’s newly launched biological context layer for AI in drug discovery. It connects and contextualizes discovery data across sequence, structure, function, mechanism, pathway, and literature in one connected representation, creating queryable biological context designed to work with the AI infrastructure around it — whether a customer’s own AI models or MindWalk’s LensAI™ platform. In either configuration, ReefIQ provides the connected context, structured retrieval, and validation layer, while reasoning happens in the AI layer above it. When paired with LensAI™, MindWalk’s reasoning and application layer, that context can inform auditable, human-in-the-loop decision support across target discovery, pan-serotype biologic design, candidate diligence, and mechanism-aware variant interpretation. Ultimately, context can become more useful with each program and measurement as relationships within the data are refined over time.

Arnout Van Hyfte, Vice President of Product Management, Mindwalk

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Arnout Van Hyfte / Beyond the AI Model: How Context Layers Help Shape Agentic AI in Drug Discovery

Arnout Van Hyfte, Vice President of Product Management,
Mindwalk

Arnout Van Hyfte joined BioStrand in 2019 as a member of the founding team and has played an important role in its evolution into what is now MindWalk. He has contributed to shaping product direction and establishing the product development foundation behind MindWalk’s LensAI platform, powered by...

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