Michael R. Rossi, PhD, FACMG is the Vice President of Translational Science and Multi-Modal Real World Evidence Solutions at ConcertAI. Prior to ConcertAI, Mike was the Division Head of Molecular Oncology for Solid Tumors at Sema4 and an Associate Professor in the Department of Genetics & Genomic Sciences at the Icahn School of Medicine at Mount Sinai in New York.
Mike has extensive expertise in genomics applications for clinical diagnostics, cancer research, and oncology clinical trials, and has authored or co-authored over 65 peer review publications focusing primarily on genomic mechanisms that drive human cancers and response to therapy. At Sema4, he developed a New York State validated comprehensive tumor/normal whole exome/whole transcriptome clinical diagnostic assay for all cancer types that was integrated with real world clinical data from Mount Sinai and external pediatric and community practice cancer centers. Prior to Sema4, had a dual appointment as an Assistant Professor at Emory University in the Department of Radiation Oncology and the Department of Pathology and Laboratory Medicine. There he developed many of the first molecular and NGS based clinical and research assays for solid tumors and hematological malignancies.
Despite advancements in immunotherapy for metastatic non-small cell lung cancer (NSCLC), a significant proportion of patients do not respond to immune checkpoint inhibitors (ICIs). Identifying effective prognostic biomarkers that are independent of squamous and nonsquamous histology is critical for optimizing treatment strategies in NSCLC. Interferon gamma (IFNG) has emerged as a potential marker for predicting immunotherapy outcomes due to its role in immune modulation independent of squamous histology