Gabriel Ozorowski | Sr. Laboratory Director
The Scripps Research Institute

Dr. Gabriel Ozorowski has over 16 years of experience in protein structural biology, with a background in applying x-ray crystallography and cryo-electron microscopy (cryoEM) techniques to biomedical studies. He focuses on conformational states of HIV-1 Env and how they are affected by ligands (antibodies, small molecules) or clinically-relevant formulation components (e.g. adjuvants). Using high resolution cryoEM, Dr. Ozorowski studies the atomic level interactions between antibodies induced by vaccination or natural infection, and viral glycoproteins. Traditionally performed using characterized monoclonal antibodies, he is now applying the same cryoEM methods to be amenable to polyclonal antibody structural elucidation. This allows for faster serum antibody readouts during vaccine trials, and at typical resolution ranges, has worked to not only describe the polyclonal antibody epitopes at atomic detail but also propose possible fragment antigen binding variable region sequences that can be searched against corresponding B cell receptor next-generation sequencing data. Additionally, he plays an active role in assessing the quality of immunogens produced for human clinical trials and testing whether formulations are compatible with trimer stability prior to administration into study volunteers.