Dr. Richman conducted research on influenza virus, herpesviruses and hemorrhagic fever viruses before focusing on HIV in the 1980s. HIV drug resistance was originally recognized in his laboratory. His lab also identified the latent HIV reservoir as the obstacle to cure with antiretroviral therapy, and the neutralizing antibody response as the selection pressure for continuing neutralization escape and envelope evolution within HIV infected individuals. In addition to his continuing interest in HIV treatment and drug resistance, his research interests have focused on HIV pathogenesis, especially the latent HIV reservoir. ( https://en.wikipedia.org/wiki/Douglas_Richman )