Sophia Karagiannis | Professor Of Translational Cancer Immunology And Immunotherapy
King's College London

Sophia Karagiannis, Professor Of Translational Cancer Immunology And Immunotherapy, King's College London

Professor Sophia Karagiannis is a translational cancer immunologist with academic and biotechnology experience in the USA and UK. She heads a cancer antibody discovery team focused on the crosstalk between patient immune cells and cancer and on the design of novel agents for solid tumours. Key areas of research include the study of patient-derived B cells and antibodies, engineering antibodies of any specificity or class/isotype, including Fc-engineered antibodies and antibody-drug conjugates for cancer therapy. Her group is the first internationally to design, evaluate and translate anti-tumour IgE class antibodies from concept to clinical testing. Sophia is a founder of Epsilogen Ltd, the first immuno-oncology company dedicated to developing IgE therapeutic agents for cancer. She is author of patents on antibody engineering for cancer therapy and serves as Secretary of the international AllergoOncology consortium, focused on the interface between Th2 immunity, allergies, IgE and cancer, now a recognised Working Group by the European Academy of Allergy and Clinical Immunology.

Appearances:



Festival of Biologics Day 2 @ 14:40

B cells and antibodies in patients with solid tumours

Cell-based and genomic evaluations reveal an active B cell immune surveillance and a B cell compartment with distinct immunoglobulin isotype profiles in cutaneous melanoma and breast cancer. Inflammatory Th2-biased conditions promote B cell class switching as a mechanism to divert the humoral response. Dissecting the humoral response and immunoglobulin profiles may uncover new insights into immunosuppressive forces in the tumour microenvironment.
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT

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