Oliver Seifert | Post-Doc
University of Stuttgart

Festival of Biologics Day 1 @ 17:30

Trispecific eFab-eIg T-cell Engagers Using the eIg Technology

• We present a novel approach to generate trispecific antibodies based on the previously developed eIg technology comprising one Fab and two eFab moieties that were fused to obtain an asymmetric eFab-eIg molecule
• The trispecific TCE retained binding activity for all three antigens (HER2, HER3 and CD3) and was capable of recruiting T-cells to HER2 and/or HER3-expressing cancer cells and mediating effective cancer cell killing, as shown in 2D and 3D model systems
• Due to the modular architecture, this approach should be suitable to generate trispecific antibodies of any specificity and for a multitude of applications

Oliver Seifert, Post-Doc, University of Stuttgart

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Oliver Seifert / Trispecific eFab-eIg T-cell Engagers Using the eIg Technology

Oliver Seifert, Post-Doc,
University of Stuttgart

Oliver Seifert is a senior scientist in the laboratory of Roland Kontermann at the University of Stuttgart and leads the bispecific antibody group. He is an expert in the field of antibody engineering with more than 20 years experience. His scientific research covers development and...

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