Luminita Damian | BDM
Cytiva

Festival of Biologics Day 2 @ 11:00

Accelerate antibody variant screening and development

Biotherapeutics is the fastest growing sector in the pharmaceutical industry.While the market is still largely dominated by monoclonal antibodies (mAbs), a growing number of non-traditional antibody formats are driving increased molecular diversity. These new formats offer advantages like dual targeting, better tissue penetration, and the ability to cross the blood-brain barrier. However, their structural complexity introduces new challenges in purification, analytics, and manufacturing.  Traditional mAb purification relies on platform methods using affinity resins like Protein A. For novel antibody formats, customized solutions are needed, and in this presentation, we will introduce new chromatography resins like MabSelect™ VH3 and MabSelect™ Mild Elution, designed to meet these evolving needs. As the biologics pipeline expands, the demand for robust, high-resolution analytics grows. Biacore™ systems provide detailed insights into titer, potency, binding kinetics, and epitope specificity across a wide range of molecule types. In this presentation we will show how selecting antibodies based on developability, efficacy, and safety is key to successful CMC progression. Case studies will include epitope binning, clone selection, bispecificity assessment, and thermal stability testing under physiological conditions. We will close by briefly mentioning PrismA ELISA™ kit, specifically designed for detecting residual PrismA protein A ligand from chromatography resins.

Luminita Damian, BDM, Cytiva

×

Luminita Damian / Accelerate antibody variant screening and development

Luminita Damian, BDM,
Cytiva

Luminita Damian is the Business Development Manager for the Biacore and Protein Imaging portfolio at Cytiva. She has held various positions at Cytiva, building nearly 20 years of experience in the life sciences sector. She received her Ph.D. in Biochemistry from Paul Sabatier University in...

CloseMore