Irwin Matyjaszczyk | Senior Scientist I
Selvita S.A

Festival of Biologics Day 2 @ 14:20

Phage Display: Current Trends and Future Directions

• Evolution of Phage Display Libraries: From early, non-rational designs to third-generation libraries enhanced by next-generation sequencing (NGS) and synthetic biology. Emerging approaches focus on data-driven design, predictive modeling, and AI to expand diversity, minimize sequence liabilities, and improve biophysical properties.
• Advancements in Panning Strategies: Modern selection strategies integrate NGS monitoring and AI support to identify diverse, antigen-specific binders. Rational and developability-oriented process design, combined with AI-guided sequence optimization, helps reduce the occurrence of sequence liabilities and negative hits.
• Integration with Advanced Technologies: Hybrid platforms incorporating microfluidics, biosensor-based rapid selection, and single-cell technologies could enable precise, high-throughput biopanning control and facilitate the screening of complex libraries.

Irwin Matyjaszczyk, Senior Scientist I, Selvita S.A

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Irwin Matyjaszczyk / Phage Display: Current Trends and Future Directions

Irwin Matyjaszczyk, Senior Scientist I,
Selvita S.A

Irwin Matyjaszczyk holds a PhD in molecular biology from the University of Wroclaw. He spent six years at Pure Biologics, where he was responsible for antibody discovery and optimization as well as method development in projects that progressed to clinical research. In 2024, he joined...

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