Monte Rosa’s QuEEN (Quantitative and Engineered Elimination of Neosubstrates) platform enables us to rationally discover molecular glue degraders (MGDs). QuEEN comprises:
- Degron encyclopedia: A growing catalogue of over 1500 proteins identified through our AI-driven approach, containing proteins of diverse protein classes across therapeutic areas, including highly credentialed targets previously deemed undruggable.
- Proprietary MGD library: A diverse and continuously growing chemical library of drug-like MGDs that are rationally designed based on our expertise in molecular glue anatomy
- Glueomics toolbox: A tailored suite of biochemical, structural biology, cellular, proteomics and in silico screening tools that connect degrons to MGDs
Leveraging QuEEN, we have identified and validated MGDs to highly validated and therapeutically relevant but undruggable proteins.