E-Drone is an EPSRC-funded research project carried-out by a consortium of UK universities (University of Southampton, Bournemouth University, UCL and University of Leeds). The project examined the energy reduction potential of integrated logistics solutions involving Uncrewed Aerial Vehicles (UAVs, commonly known as drones) operating alongside traditional and sustainable last-mile delivery modes (e.g., vans, cargo cycles). The project used a case study approach based around NHS patient diagnostic sample transportation involving simulated and live trials across the Solent region. Key research areas were: