Gudrun Thorhallsdottir | Research Scientist Associate
Philochem AG

Festival of Biologics Day 1 @ 15:20

Turning Cold Tumors Hot: Targeted TNF Potentiates the Activity of Bispecific T Cell Engagers in Solid Tumors

Cold tumors remain largely unresponsive to T cell engagers (TCEs) due to the immunosuppressive tumor microenvironment and poor T cell infiltration. Here, we show that targeted TNF delivery potentiates CD3-based TCE activity, leading to robust tumor eradication in vivo. Cured mice resisted tumor rechallenge, demonstrating long-term protective immunity. Mechanistically, TNF remodeled the tumor microenvironment, promoting sustained T cell infiltration and durable antitumor memory.

Gudrun Thorhallsdottir, Research Scientist Associate, Philochem AG

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Gudrun Thorhallsdottir / Turning Cold Tumors Hot: Targeted TNF Potentiates the Activity of Bispecific T Cell Engagers in Solid Tumors

Gudrun Thorhallsdottir, Research Scientist Associate,
Philochem AG

Gudrun Thorhallsdottir is a Research Associate Scientist at Philochem AG and Doctoral student at ETH Zürich, where she focuses on the development of novel antibody-based therapeutics.  

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