Veronique Chotteau | Principal Investigator
K.T.H. Royal Institute of Technology

Veronique Chotteau, Principal Investigator, K.T.H. Royal Institute of Technology

Dr. Chotteau has ≥ 25 years of experience in mammalian cell culture including ≥ 10 years in biopharmaceutical industry. Her expertise covers process development (perfusion, fed-batch, stem cell bioprocessing, small-, pilot- and commercial scale, GMP). Dr. Chotteau has worked at Pharmacia Upjohn/Biovitrum, Stockholm, (nowadays Swedish Orphan Biovitrum) between 1996 and 2008 with different responsibilities: project manager for process development (e.g. recombinant factor VIII ReFacto®, antibody), CDMO business development support for the evaluation of new projects, head of pilot plant, expert in animal cell culture development (small, pilot and commercial size/GMP). In 2008, Dr. Chotteau was offered to lead the animal cell cultivation activities, due to her expertise in cell culture and her industrial background. Since then, her group has focused on cell-based processes for biopharmaceutical production and on stem cell bioprocessing. Her group has performed/is performing several projects of perfusion process at high cell density, metabolic flux analysis, purification by magnetic beads and development of fed-batch process for biopharmaceutical production. Her group is part of the Wallenberg Centre for Protein Research, Sweden. 

Appearances:



Advanced Therapies and Regenerative Medicine Day 2 - Thursday 17th May 2018 @ 12:40

High cell density perfusion process of human cells for the production of biopharmaceutical

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  •     Human cell-based systems might bring important advantages compared to CHO cells, the workhorses of the biopharmaceutical field
  •     High cell density perfusion process at density up to 100 x 10^6 HEK 293 cells/mL was developed for EPO production to evaluate the potential of these cells for biopharmaceutical production
  •     A novel scale-down perfusion bioreactor of 200 mL working volume was developed

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