Igor D'Angelo | Senior Scientist and Functional Lead
Amgen Inc

Igor D'Angelo, Senior Scientist and Functional Lead, Amgen Inc

I’m a graduate from the University of Pavia (Italy) and with a PhD in Structural and Computational Biology from Uni Heidelberg/EMBL, where I spent four fantastic years working on neurodegenerative disease NF1. I then moved to Vancouver and joined the lab of Dr.Strynadka at UBC, renowned for its expertise in bacterial secretion systems. After my postdoc I experienced ‘frigid but stunning’ Saskatchewan, working as scientist at the Canadian Light Source’s Crystallography Beamlines. Craving for the West Coast, I then joined Zymeworks, a local Vancouver biotech, helping it grow from 5 to 150 employees, and into a major player in our field. Having a thirst to experience the big pharma world, I then moved to Amgen, where I have been leading the Ab engineering team in Discovery Research for more than two years.


European Antibody Congress 2018, Day 1 @ 18:10

Structure guided rational design of de novo antibody specificity

  • Engineered rat specificity de novo into Amgen’s lead anti-migraine molecule (AMG334
  • Fine tuning of specificity to gain Rat specificity without losing the human one
  • Structural computational approach, used in parallel with other engineering yielding the best results in terms of time vs effort vs cost
  • Investigated deep sequencing to enhance and de-risk the Ab engineering process
last published: 29/Oct/18 16:25 GMT
last published: 29/Oct/18 16:25 GMT

back to speakers

There are two parts to the Festival of Biologics: the five world-class international conferences covering Antibodies, Immunotherapy, BioSimilars, Clinical Trials, and High Potency APIs; and an exhibition featuring the most exciting technology and solutions for pharma and biotech. There is a registration fee to attend the conferences. To visit the exhibition is free.


Conference 29 - 31 October • Exhibition & Seminars 29 - 31 October

Sign Up for Event Updates