BioData EU 2018 - Agenda Day 2

 

BioData EU- Day 2

08:55

Chair’s opening remarks

Mene Pangalos
09:00

Transforming R&D productivity: How can we better turn science into medicine?

  • The future treatment for many of today’s diseases lies in discovering new biology to develop novel therapies. The advent of the genomics revolution brings with it an expanding list of pathways and targets to pursue – and with it, new drug discovery challenges
  • Validating drug targets by understanding and challenging scientific hypotheses has never been more important
  • Combining new technologies, focusing on medical understanding, challenging scientific hypotheses and driving strategic partnerships, we are making real progress in our ability to define and prosecute innovative treatment approaches for a variety of complex diseases
09:20

Sponsor keynote

Harpreet Sood
09:40

New plans for the digital architecture across the NHS

Harpreet Sood, Associate Chief Clinical Information Officer, NHS England
10:00

Day One Initiative

Morning Refreshments

AI, AUTOMATION AND MACHINE LEARNING

ANALYTICS PLATFORMS AND DATA SETS

NEXT GEN SEQUENCING

DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS

ROCHE CURATED SESSION

Track 5- AI, AUTOMATION AND MACHINE LEARNING
11:00

Chairs Opening Remarks

Track 6- ANALYTICS PLATFORMS AND DATA SETS/ CLOUD PLATFORMS/ SOFTWARE & APPLICATIONS
11:00

Chairs Opening Remarks

Track 7- NEXT GEN SEQUENCING / REAL WORLD EVIDENCE
11:00

Chairs Opening Remarks

Track 8- DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS
11:00

Chairs Opening Remarks

Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
11:00

Chairs Opening Remarks

Track 6- ANALYTICS PLATFORMS AND DATA SETS/ CLOUD PLATFORMS/ SOFTWARE & APPLICATIONS
11:05

Using analytics tools to leverage data

Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
11:05

ROCHE CURATED SESSION

Track 5- AI, AUTOMATION AND MACHINE LEARNING
11:25

Sponsor Available

Track 6- ANALYTICS PLATFORMS AND DATA SETS/ CLOUD PLATFORMS/ SOFTWARE & APPLICATIONS
11:25

Sponsor Available

Track 7- NEXT GEN SEQUENCING / REAL WORLD EVIDENCE
11:25

Sponsor Available

Track 8- DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS
11:25

Sponsor Available

Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
11:25

Sponsor Available

Track 5- AI, AUTOMATION AND MACHINE LEARNING
11:45

Presentation

Track 6- ANALYTICS PLATFORMS AND DATA SETS/ CLOUD PLATFORMS/ SOFTWARE & APPLICATIONS
11:45

Machine Learning meets the Human Genome

Track 7- NEXT GEN SEQUENCING / REAL WORLD EVIDENCE
11:45

A comprehensive analysis of a RNA-seq dataset at the gene-, isoform- and exon-levels to discover disease progressive biomarkers during diabetic nephropathy

  • Introduction to ZSF1, a preclinical model for type 2 diabetic nephropathy
  • Why RNA-seq data should be additionally analyzed at the isoform and exon levels
Track 8- DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS
11:45

Use case: Federated EHR research technology to support clinical trial protocol optimisation: Evidence from EHR4CR and the InSite platform

  • The new federated EHR technology approach – the case of EHR4CR project and deployment program inEurope
  • Utilise a combination of data sources to effectively structure your developmental strategy
  • Outlook on performing Pragmatic Clinical Trials & Conclusions
Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
11:45

ROCHE CURATED SESSION

12:05

Round Tables

Roundtables 1: AI in LongevityDmitry Kaminskiy, Co-founder, Senior Partner, Deep Knowledge Ventures+Roundtable 2: Patient advocacy within clinical trialsMimi Choon-Quinones, Executive Senior Director, Clinical Operations and Patient Engagement, Arena Pharmaceuticals+Round table 3: GDPRGreg Lefebvre, Genomic Data Science Team Lead, Nestle Institute of Health SciencesJerome Carayol, Data Analyst, Nestle Institute of Health SciencesArmand Valsesia, Project Lead and Senior Specialist in Statistical Genetics, Nestle Institute of Health SciencesAlix (Leboucq) Zollinger, Genomics Data Analyst, Nestle Institute of Health Sciences+Round table 4: Analytics for Regulatory and Safety RWE and EpidemiologyAndrew Bate, Senior Director, Analytics Team Lead, Epidemiology, Pfizer+ Round table 5: Digital Endopoints and ValidationJohn Batchelor, Senior Outcomes Measurement Scientist, Roche

Networking Lunch

AI, AUTOMATION AND MACHINE LEARNING

ANALYTICS PLATFORMS AND DATA SETS

NEXT GEN SEQUENCING

DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS

PRECISION MEDICINE

Track 5- AI, AUTOMATION AND MACHINE LEARNING
14:05

Chairs Opening Remarks

Track 6- ANALYTICS PLATFORMS AND DATA SETS/ CLOUD PLATFORMS/ SOFTWARE & APPLICATIONS
14:05

Chairs Opening Remarks

Track 7- NEXT GEN SEQUENCING / REAL WORLD EVIDENCE
14:05

Chairs Opening Remarks

Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
14:05

Chairs Opening Remarks

Track 6- ANALYTICS PLATFORMS AND DATA SETS/ CLOUD PLATFORMS/ SOFTWARE & APPLICATIONS
14:10

Applied Technology and Innovation

Track 7- NEXT GEN SEQUENCING / REAL WORLD EVIDENCE
14:10

Different whole genome sequencing strategies to study HPVs role in cancer development.

  • How HPV is involved in the development of different cancers
  • Strengths and weaknesses of different whole genome sequencing strategies to study HPV integrations in cancer
  • Time vs Money where should you invest?
Track 8- DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS
14:10

Application of ML to lupus nephritis and extrarenal lupus clinical dataset - lesson learned and main takeaways

  • We adapted Eureqa software (Nutonian) to screen baseline and time-varying clinical and laboratory parameters for associations with outcome using pooled data from recent trials in lupus nephritis (LN) and extrarenal lupus (ERL)
  • In LN, Eureqa confirmed known associations with outcome but also several trivial associations. Eureqa did not identify meaningful associations between clinical variables and outcome in ERL trials
  • Eureqa is a potentially exciting tool to assist with discovery of novel associations in clinical data and hypothesis generation
Track 5- AI, AUTOMATION AND MACHINE LEARNING
14:30

Copyright Clearance Center

Track 6- ANALYTICS PLATFORMS AND DATA SETS/ CLOUD PLATFORMS/ SOFTWARE & APPLICATIONS
14:30

Sponsor Available

Track 7- NEXT GEN SEQUENCING / REAL WORLD EVIDENCE
14:30

Using AI for drug target discovery

  • Case studies over the last five years
  • Precision Medicine based clinical trials
  • RWE in practice
Track 8- DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS
14:30

Sponsor Available

Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
14:30

Sponsor Available

Track 7- NEXT GEN SEQUENCING / REAL WORLD EVIDENCE
14:50

Omics and pathway analysis for disease understanding in pain

  • Pain as a disease
  • Interpretation of Omics data and Pathways
  • Pain Landscapes and Disease Understanding
Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
14:50

Precision and recall oncology: combining multiple gene alterations for improved identification of drug-sensitive tumours

  • A small proportion of tumours present strong gene-drug response associations that can be used as predictive biomarkers of drug response.
  • Combining multiple gene alterations of the tumours via Machine Learning (ML) often results in better discrimination than that provided by the corresponding single-gene marker.
  • ML multi-gene predictors generally retrieve a much higher proportion of treatment-sensitive tumours (i.e. they have a higher recall). This suggests that substantially more patients could eventually benefit from effective drug selection by applying this ML methodology to existing clinical pharmacogenomics data sets

AI, AUTOMATION AND MACHINE LEARNING

SOFTWARE & APPLICATIONS

EVIDENCE

DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS

PRECISION MEDICINE

Track 5- AI, AUTOMATION AND MACHINE LEARNING
15:40

Presentation

Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
15:40

Comprehensive DNA NGS panels provide the depth and width required for a full range of companion diagnostic uses in oncology

  • Landscape of multi-gene DNA biomarkers
  • Promise of comprehensive gene panels
  • Detail of panel design beyond gene name important for catching various types of variation
Track 5- AI, AUTOMATION AND MACHINE LEARNING
16:00

Sponsor Available

Track 6- ANALYTICS PLATFORMS AND DATA SETS/ CLOUD PLATFORMS/ SOFTWARE & APPLICATIONS
16:00

Sponsor Available

Track 7- NEXT GEN SEQUENCING / REAL WORLD EVIDENCE
16:00

Sponsor Available

Track 8- DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS
16:00

Sponsor Available

Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
16:00

Sponsor Available

Track 6- ANALYTICS PLATFORMS AND DATA SETS/ CLOUD PLATFORMS/ SOFTWARE & APPLICATIONS
16:20

How to Infuse the Human Perspective to Digital Health?"

  • Most paradigms of the digital health revolution, such as digital therapeutics, precision medicine, outcome-based health systems, and self-care are critically dependent on changing behavioural aspects of patients
  • Impactful digital health initiatives are therefore best co-developed with patients in a human-centric manner
  • Patients can participate in product and service development at scale through a novel service platform for patient engagement, specifically trained resources, and a network of relevant partners
Track 8- DATA MANAGEMENT AND GENOMICS IN CLINICAL TRIALS
16:20

Surfing the Tsunami Opportunities and Challenges of Digital in Clinical at Abbvie

Kyle Holen, Head of Development Design Center, AbbVie
Track 9- ROCHE CURATED SESSIONS/ PRECISION MEDICINE
16:20

The Genomics of Rare Diseases at Boston Children’s Hospital

  • The importance of phenotyping, transparency, and patient engagement
  • The delicate balance of data sharing, discovery, and translation to the clinic
  • Case studies of big data projects at a tertiary children’s hospital
  • Collaborations with Industry to make rare disease discoveries

End of Conference

last published: 20/Jul/18 15:45 GMT

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Contact us

To sponsor or exhibit contact:
Alistair Wilmot
+44 (0)207 092 1174

alistair.wilmot@terrapinn.com


To speak:
Chris Shanks
+44 (0)207 092 1151

chris.shanks@terrapinn.com