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Design of a “Universal” Influenza Synthetic Peptide Vaccine.

Robert S. Hodges from the Department of Biochemistry & Molecular Genetics, University of Colorado School of Medicine, joined us at the World Vaccine Congress in Washington in April 2012 to discuss the development of a Universal Influenza Synthetic Peptide Vaccine based on highly conserved regions of hemagglutinin (HA). The aim of this research is to provide broad and long lasting protection against many subtypes of influenza, which would not need to be changed annually and would protect against antigenic drift and antigenic shift variants. The necessity for such a vaccine is evident as the influenza annual toll is more than a billion cases. A ‘Universal Vaccine’ would dramatically reduce economic burden of health care costs, lost work days and loss of life.

Why not download the full presentation and get more details about their plan to produce a universal influenza vaccine:

Begin by identifying the conserved a-helical segments in the stem region of HA from different subtypes. The design template a-helical coiled-coil peptide immunogen. Followed by eliciting rabbit anti-peptide antibodies that cross-react with native HA protein and then being able to determine the efficacy of antibodies in animal model of infection.

Download the full presentation here!

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