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Presentation: Marian Major

Dr Marian Major, Research Microbiologist, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research at FDA joined us at the 12th annual World Vaccine Congress in Washington DC to discuss the challenges and perspectives on Hepatitis C Vaccines.

Challenges to HCV Vaccine Development:

  • Natural isolates exist as quasispecies populations. Several genotypes identified (GT 1-6). 
  • Greatest diversity in natural isolates is observed in the envelope region. 
  • Only animal model for HCV pathogenesis is the chimpanzee 
  • Biomarkers of protection still need to be identified. Cross reactive neutralizing antibodies have been identified but T-cell phenotypes important for protection have not been determined.

For the whole presentation and details on the above mentioned focus points, please download the presentation here.

 

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