Zoran Ivanovic | Scientific Director
French Blood Institute, région Nouvelle Aquitaine

Zoran Ivanovic, Scientific Director, French Blood Institute, région Nouvelle Aquitaine

Zoran Ivanovic received his MD and PhD in Experimental Hematology at Faculty of Medicine, and also his MSc degree in System and Comparative Physiology at the Faculty of Science of Belgrade University. He specialized in Transfusion (Bordeaux 2 University) and in Cell Therapy (Paris 7 University). He received the “HDR” (Habilitation à Diriger les Recherches) Degree at Bordeaux 2 University.

He 1989 he was a research assistant at the Institute of Medical Research, Belgrade, where he received the title of Research Professor in 1998. He was appointed Associate Professor of Hematology at the Medical Faculties of Limoges University and Bordeaux 2 University in the period 1999-2002. Since 2002, he has been Scientific Director of French Blood Institute for the regions of Aquitaine and Limousin (since 2018 of Nouvelle Aquitaine) where he founded his research laboratory in 2003. Since 2011 he is a guest professor at the Medical faculty of Nis University (Serbia) and from 2015 adjunct professor of Luxembourg University. Dr Ivanovic is full member of Medical Sciences Academy of Serbian Medical Society.

Dr Ivanovic published some pioneer works on the induction of stem cell self-renewal at low O2 concentration. More than one decade-long work on this issue allowed him to develop his concept “Evolutionary Oxygen Stem Cell Paradigm” (Anaerobiosis and stemness: an evolutionary paradigm, Elsevier 2016) considering “anaerobic”, low-energy proliferation to be in fact a key of self-renewal: low availability of energy preventing cells from differentiating, which requires much more energy than simple cell division not coupled with differentiation. This feature of stem cells seems to reflect the ancestral, primitive mono-cellular organisms existing at the time when atmosphere oxygen concentration was still very low. This concept, applied to cell engineering enabled Dr Ivanovic and his group to develop clinical-scale ex-vivo expansion procedures combining an anti-oxidants-supplied medium with cytokines mimicking the effects of a low O2 concentration in order to neutralize the negative effects of hyper-oxygenation (20-21% O2), as well as to design a completely new and original approach of stem and progenitor cell conservation in hypothermia. 

Dr Ivanovic holds several grants in the field of cord blood and adult stem cell research. He has published 125 papers (mainly in peer reviewed journals) and book chapters; he realized 150 meeting communications and invited conferences and supervised several PhD and master thesis. Dr Ivanovic serves as Academic Editor/Editorial board member of PLoS One, Editorial board member of Transfusion Clinique et Biologique and acts frequently as reviewer for several scientific journals (J Cell Physiol, PLoS One, Stem cells, Haematologica...).  


Conference Day 1: Thursday 16th May 2019 @ 15:10

Improvement of functional preservation of cord blood stem and progenitor cells stored at +4°C after collection or after ex vivo expansion: development of a potentially injectable conservation solution

  • After ex vivo expansion, the hematopoietic stem cells (Scid Repopulating Cells) rapidly decline in human-albumin solution (used routinely) and their activity is almost completely lost after 48h. This can be prevented by using an appropriate culture medium instead of human albumin (antioxidants, nutritive elements, microelements).
  • The decline of hematopoietic stem cell activity (although to a lesser extent) detected after cord blood collection using the standard routine procedure can be prevented by using the same culture medium.
  • This medium is not an optimal choice since it should be removed before injection of the cells into the patient. Thus, we have developed a conservation solution composed of already registered injectable pharmaceutical products, able to reproduce the same beneficial effect using both freshly collected cord blood cells and ex vivo expanded ones
last published: 14/May/19 13:35 GMT

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