Dr Jonathan Davis | Principal Scientist, Molecular Structure and Design
Bristol Myers Squibb

Dr Jonathan Davis, Principal Scientist, Molecular Structure and Design, Bristol Myers Squibb

Jonathan Davis received his Ph.D. from UC San Francisco, followed by a post-doc at Harvard Medical School in the labs of Jack Szostak and Gerhard Wagner. He then joined EMD Serono in Billerica, MA, where he invented a platform technology for generating heterodimeric Fcs and developed a novel scaffold based on an artificially-designed protein. He has extensive experience in selection technologies, library design, in silico modeling, and therapeutic discovery. In 2008 he moved to Bristol-Myers Squibb, where he is a Principal Scientists in Molecular Structure and Design, applying his skills to a wide range of challenges in protein and peptide engineering.

Appearances:



EAC 2017 Day 2, Wednesday 1st November 2017 @ 15:15

Information content and molecular complexity: how important are the size and design of libraries?

  • Selections for HIV-1 entry inhibitors used a variety of libraries
  • We analyzed the winning sequences, to determine how the library design may have dictated their emergence
  • The role of library design and library size will be examined
  • Results may lead to a deeper understanding of how to set up successful selections

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