Dr Haruki Hasegawa | Principal Scientist

Dr Haruki Hasegawa, Principal Scientist, Amgen

Haruki is a molecular cell biologist who specializes in investigating the processes of in vivo protein folding and intracellular trafficking of therapeutically important proteins. His main research interests are to (1) elucidate cargo-specific biosynthetic mechanisms for broad classes of proteins and their fate in intracellular and extracellular space after the synthesis. After receiving a Ph.D. in Molecular Cell Biology from the University of Michigan, Haruki undertook a postdoctoral training at the National Institutes of Health, Bethesda. In Amgen, Haruki works with disease area specialists, geneticists, and assay technology experts to advance early exploratory projects from target validation and proof-of-concept studies to lead selection and optimization.


EAC 2017 Day 2, Wednesday 1st November 2017 @ 17:20

Assessing mAb’s CMC related properties during early lead discovery stage by using endoplasmic reticulum as a physiological test tube

  • Depending on the properties embedded in the VL and VH regions, some mAbs show undesirable condensation propensity at high protein concentrations
  • Condensation-prone IgG mAbs can induce three different prominent cellular phenotypes during overexpression in mammalian cells
  • This talk will illustrate the predictive values of overexpression-induced cellular phenotypes in assessing the solution behaviors of individual mAb clones

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