Hooman Hefzi | Systems Biochemistry and Cell Engineering
U.C.S.D. | United States

Hooman Hefzi, Systems Biochemistry and Cell Engineering, U.C.S.D.

Hooman is a 6th year Ph.D. candidate in the Systems Biochemistry and Cell Engineering lab of Dr. Nathan Lewis at UC San Diego. His research focuses on integrating multiomic datasets to understand Chinese hamster ovary (CHO) cell behavior for applications in cell line engineering and optimal bioprocess design. In the course of his studies he has led an effort to construct a consensus genome-scale model of metabolism in CHO cells and identified an engineering strategy to completely eliminate lactate production in this cell line.


Cell Culture World Congress 24th May @ 16:00

Elimination of lactate production in CHO cells

Cell Culture Master
  • Complete knockout of lactate dehydrogenase
  • Drastic decrease in required base addition for pH stability in culture
  • Knockout cells exhibit prolonged growth in fed-batch culture

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