Dr Daniel Adriano Silva Manzano | Senior Research Fellow
University Of Washington
My academic foundation is in Biomedical Research, since my PhD (National University of Mexico) I have focused on the computational modeling of protein folding and function. I completed my first postdoc at the Hong Kong University of Science and technology under the supervision of Professor Xuhui Huang, where I researched long timescale dynamics of RNA Polymerase II using Molecular Dynamics and Markov State Models. Afterwards I transitioned to Professor's David Baker Group (University of Washington) where my focus has been engineering novel protein-protein interfaces which can be used as therapeutic drugs, biosensors and molecular switches. My work involves development of theoretical/computational frameworks for protein design as well as its experimental validation.My academic foundation is in Biomedical Research, since my PhD (National University of Mexico) I have focused on the computational modeling of protein folding and function. I completed my first postdoc at the Hong Kong University of Science and technology under the supervision of Professor Xuhui Huang, where I researched long timescale dynamics of RNA Polymerase II using Molecular Dynamics and Markov State Models. Afterwards I transitioned to Professor's David Baker Group (University of Washington) where my focus has been engineering novel protein-protein interfaces which can be used as therapeutic drugs, biosensors and molecular switches. My work involves development of theoretical/computational frameworks for protein design as well as its experimental validation.My academic foundation is in Biomedical Research, since my PhD (National University of Mexico) I have focused on the computational modeling of protein folding and function. I completed my first postdoc at the Hong Kong University of Science and technology under the supervision of Professor Xuhui Huang, where I researched long timescale dynamics of RNA Polymerase II using Molecular Dynamics and Markov State Models. Afterwards I transitioned to Professor's David Baker Group (University of Washington) where my focus has been engineering novel protein-protein interfaces which can be used as therapeutic drugs, biosensors and molecular switches. My work involves development of theoretical/computational frameworks for protein design as well as its experimental validation.My academic foundation is in Biomedical Research, since my PhD (National University of Mexico) I have focused on the computational modeling of protein folding and function. I completed my first postdoc at the Hong Kong University of Science and technology under the supervision of Professor Xuhui Huang, where I researched long timescale dynamics of RNA Polymerase II using Molecular Dynamics and Markov State Models. Afterwards I transitioned to Professor's David Baker Group (University of Washington) where my focus has been engineering novel protein-protein interfaces which can be used as therapeutic drugs, biosensors and molecular switches. My work involves development of theoretical/computational frameworks for protein design as well as its experimental validation.My academic foundation is in Biomedical Research, since my PhD (National University of Mexico) I have focused on the computational modeling of protein folding and function. I completed my first postdoc at the Hong Kong University of Science and technology under the supervision of Professor Xuhui Huang, where I researched long timescale dynamics of RNA Polymerase II using Molecular Dynamics and Markov State Models. Afterwards I transitioned to Professor's David Baker Group (University of Washington) where my focus has been engineering novel protein-protein interfaces which can be used as therapeutic drugs, biosensors and molecular switches. My work involves development of theoretical/computational frameworks for protein design as well as its experimental validation.My academic foundation is in Biomedical Research, since my PhD (National University of Mexico) I have focused on the computational modeling of protein folding and function. I completed my first postdoc at the Hong Kong University of Science and technology under the supervision of Professor Xuhui Huang, where I researched long timescale dynamics of RNA Polymerase II using Molecular Dynamics and Markov State Models. Afterwards I transitioned to Professor's David Baker Group (University of Washington) where my focus has been engineering novel protein-protein interfaces which can be used as therapeutic drugs, biosensors and molecular switches. My work involves development of theoretical/computational frameworks for protein design as well as its experimental validation.
Appearances:
Day 1 Antibody Congress @ 15:20
De novo computational design of hyperstable miniprotein binders
Plenary- New paradigm for protein design that allows accurate engineering and subsequent experimental characterization of computationally designed hyperstable de novo miniprotein binders.
- Examples of successfully engineered high-affinity binders and demonstrate how by massively encoding controlled variations of our designs we are able to prove multiple hypotheses of protein folding and binding, such as the importance of loop topology, hydrophobic cores and the role of disulfide bonds.
- Results reveals unprecedented agreement between state-of-the-art computational metrics and experiments.
Organiser
