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Bo Kara- European Antibody Congress 2013Overcoming Manufacturing Challenges and Streamlining the Development of Antibody Drug Conjugates

Bo Kara joined us at the European Antibody Congress 2013 to discuss ADC Development Challenges. Download his presentation to find out more about the following challenges that can occur during the development of ADCs:

    Antibody
–Selection of lead antibody candidate?
–Antibody engineering to control heterogeniety?
–Solvent accessibility, impact on thiol reactive linkers and ‘activity’?
–Site specific conjugation technologies?

    Conjugation
–Site of conjugation and impact on stability and pharmacokinetics
–Extent of and control of heterogeniety
–DAR optimisation and characterisation
–Optimisation and control of reaction steps
–ADC analytics

    Formulation
–Antibody – generally track record of stability
–BUT: Many small molecule drugs relatively hydrophobic: potential for hydrophobicity driven aggregation?
–Conjugation vs lysine – potential to reduce number of protein surface charges – hydrophilicity?
–Impact on ADC stability or solubility vs naked antibody?

    Cost of goods

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Thanks,
European Antibody Congress Team.