Understanding the factors that drive stability of protein conjugates
- Antibodies with cysteine mutations for conjugation are widely used for the preparation of homogeneous ADCs with defined molar ratios between the payload to the antibody.
- The factors that drive stability are not well understood.
- How we have optimized our cysteine engineering (THIOMAB™) technology to build better ADCs at Genentech will be discussed.
Dr Hans Erickson, Director of Protein Chemistry, Genentech