David Schaffer | Professor, Chemical And Biomolecular Engineering, University Of California, Berkeley And Co-Founder
4D Molecular Therapeutics

David Schaffer, Professor, Chemical And Biomolecular Engineering, University Of California, Berkeley And Co-Founder, 4D Molecular Therapeutics

David Schaffer is the Hubbard Howe Professor of Chemical and Biomolecular Engineering, Bioengineering, and Neuroscience at the University of California, Berkeley, where he also serves as the Director of the Berkeley Stem Cell Center. He received a B.S. from Stanford University in 1993 and a Ph.D. from MIT in 1998. He then conducted a postdoctoral fellowship at the Salk Institute for Biological Studies before joining the Berkeley in 1999. There, he applies engineering principles to enhance stem cell and gene therapies, work that includes novel approaches for molecular engineering and evolution of new viral vectors as well as new technologies to investigate and control stem cell fate decisions. He has published >200 papers, is an inventor on >50 patents, and has received recognitions including the American Institute of Chemical Engineers Pharmaceutical and Bioengineering Award, the American Chemical Society Marvin Johnson Award, the ACS BIOT Division Young Investigator Award, and the Biomedical Engineering Society Rita Shaffer Young Investigator Award.

Appearances:



Conference Day 2 - Wednesday 1st April 2020 @ 11:20

Directed evolution of novel aden-associated viral vectors for clinical gene therapy

  • Adeno-associated viral vectors are increasingly succeeding in the clinic, leading to several regulatory approvals
  • Vectors based on natural versions of AAV suffer from numerous shortcomings, requiring high dosages, invasive routes of administration, and/or limited efficacy for many targets
  • Our directed evolution approach involves high throughput selection of highly optimized AAVs from a library of a billion variants

Conference Day 2 - Wednesday 1st April 2020 @ 15:00

Panel discussion: Exploring advances in gene editing technology, research and ethical questions

last published: 04/Jun/20 08:25 GMT

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