Dr Alessandro Sette | Professor, Head and Member
La Jolla Infectious Disease Institute

Dr Alessandro Sette, Professor, Head and Member, La Jolla Infectious Disease Institute

Dr. Alessandro Sette has devoted more than 30 years to understanding and measuring immune responses, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. Dr. Sette laboratory is focused on the study of the specific structures (epitopes) that the immune system recognizes, and uses this knowledge to define the immune signatures associated with protective immunity versus immunopathology. 

Dr. Sette is the Head of LJI's Division of Vaccine Discovery. He created and directs since the early 2000s the Immune Epitope Database (IEDB), a freely available, widely used bioinformatics resource. Dr. Sette has a doctorate in Biological Sciences from the University of Rome and was a postdoctoral fellow at the National Jewish Center in Denver, Colorado. In 1988, Dr. Sette joined Cytel Corp. and in 1997 founded Epimmune, where was VP of Research and Chief Scientific Officer until 2002, when he joined LJI.


Agenda Day 2 @ 4:30

Immune profiling of T cell responses correlating with pertussis vaccine efficacy

  • Introduction of a whole cell pertussis vaccine in the 1950s led to dramatic reduction in morbidity
  • Whole pertussis inactivated vaccine was associated with significant side effects, replaced in 1997 with acellular version
  • Resurgence of pertussis in teenagers – age of people affected correlates with time when vaccine switched from whole cell vaccine to acellular vaccine occurred
  • Discussion of changes that have been identified in in immune profile between old vaccine and new

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