Dr. Duffy is an internationally recognized expert and scientist whose research focuses on human malaria. He is well-experienced in human observational and interventional studies of malaria, as well as mentorship of young scientists in US and Africa, making him well-suited to contribute to the objectives proposed in this application. As the Chief of the Laboratory of Malaria Immunology and Vaccinology (LMIV) at NIAID/NIH, he is responsible for the intramural NIAID program to develop and test malaria vaccines in humans. Under his leadership, LMIV has developed the first malaria transmission-blocking vaccines to enter field trials, has partnered with the local biotech Sanaria to conduct field efficacy trials of whole organism malaria vaccines for the first time, and is now pioneering a path to test the most promising malaria vaccines in pregnant women in partnership with Mali colleagues. Before taking this position in Nov 2009, he served as Malaria Program Director at Seattle Biomedical Research Institute, as Affiliate Professor of Global Health at the University of Washington, and as PI of the Fogarty-funded East African regional training program for young biomedical scientists. He has been the primary mentor to more than 60 scientists who have pursued postgraduate or postdoctoral training in his program. He received his medical degree from Duke University, his internal medicine training at Walter Reed, and his postdoctoral training in molecular vaccine development at NIH.