I direct the Laboratory of Malaria Immunology and Vaccinology, where research teams focus on pathogenesis, immunity, and vaccine development. I have extensive experience in human observational and interventional studies of malaria, including studies of controlled human malaria infections. As the Chief of the Laboratory of Malaria Immunology and Vaccinology (LMIV) at NIAID/NIH, I am responsible for the intramural NIAID program to develop and test malaria vaccines in humans. LMIV has developed the first malaria transmission-blocking vaccines to enter field trials, has partnered with the local biotech Sanaria to conduct the first field efficacy trials of whole organism malaria vaccines, and has pioneered paths in partnership with Mali colleagues to test the most promising vaccines to protect women from pregnancy malaria.