Marie-Louise Lunn | Global Senior Product Manager
Novo Nordisk Pharmatech

Main Congress Day 2 - 23rd April @ 12:10

Enhancing cell-based vaccine production with new animal-free recombinant proteins

Vaccine production is challenging not the least since it is based on biological systems, requiring high attention to patient safety but also because vaccine productions must be easy scalable and responsive to sudden local or global epidemic and pandemic situations. The use of high-performing raw materials is crucial for ensuring safe and efficient manufacturing of vaccines. Trypsin is an essential reagent in cell-based vaccine production facilitating virus expansion as well as playing an important role in activating specific virus particles including influenza. Despite rigorous testing of raw materials, the use of animal-derived trypsin carries the risk of introducing adventitious contaminants to the final vaccine product. Hence, infection of cell cultures has potentially serious consequences for patients and production continuity. The new enzyme TrypsiNNex® addresses safety and consistency concerns. TrypsiNNex® is high-purity, recombinantly produced, animal-free trypsin, enabling a more robust production and reducing the risk for contamination. A controlled production process ensures TrypsiNNex® is being expressed and maintained in an inactive form until stabilization resulting in a high and consistent proportion of β-trypsin. This makes it ideal for virus-vaccine production. In this presentation, we will show how TrypsiNNex® can optimize the production of influenza vaccines.

Marie-Louise Lunn, Global Senior Product Manager, Novo Nordisk Pharmatech

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Marie-Louise Lunn / Enhancing cell-based vaccine production with new animal-free recombinant proteins

Marie-Louise Lunn, Global Senior Product Manager,
Novo Nordisk Pharmatech

Marie-Louise Lunn is Global Product Manager at Novo Nordisk Pharmatech with on enzymes for bioprocessing. She holds a Ph.D. in molecular biology and drug discovery from the University of Copenhagen, Denmark. After working as a postdoctoral researcher at the Salk Institute for Biological Studies in...

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