Douglas Gladue | Senior Scientist, Plum Island Animal Disease Center

Douglas Gladue, Senior Scientist, Plum Island Animal Disease Center, USDA

Douglas Gladue, Ph.D., is a Senior Scientist at the Foreign Animal Disease Research Unit, Agricultural Research Service at Plum Island Animal Disease Center. For over a decade, his research has focused on the molecular mechanisms of viral pathogenesis and virus-host protein interactions and applying these discoveries to the design of rational vaccines for foreign animal viral diseases. He has discovered over one hundred host-viral protein interactions and has used this discovery combined with a custom computational pipeline involving both bioinformatic and functional genomic data, to identify critical domains in viral proteins. Deletion or mutation of these domains has been used as a basis to develop rationally designed vaccines for both classical swine fever virus (CSFV) and foot-and-mouth disease virus (FMDV).  With no commercial vaccine and recent outbreaks of ASFV affecting the Caucasus and Eastern Europe, Dr. Gladue has focused his research on developing a novel rationally designed ASFV vaccine. His recent accomplishments include the functional characterization of ASFV proteins and the development of new methodology for independent multiple deletions in the ASFV genome, allowing for safer ASFV vaccine design strategies.  Dr. Gladue has served on multiple scientific committees, authored numerous peer-reviewed scientific publications, and holds multiple patents in the field of foreign animal diseases.

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