Mark Mamula | Professor Of Medicine Rheumatology
Yale University

Dr. Mamula is a Professor of Medicine in the Yale University School of Medicine.  Dr. Mamula’s research interests are in investigating the early events involved with breaking immune tolerance to self proteins, both in autoimmune disease and in tumor biology.  Overall, it is the goal of Dr. Mamula’s laboratory to understand the mechanisms that may shift the balance toward the initiation of anti-self immune responses. Seminal work from the Mamula lab elucidated the proteomics and biochemical forms of autoantigens capable of breaking immunologic tolerance to intracellular autoantigens in systemic lupus erythematosus (SLE) and type I diabetes (T1D).  Recent studies have investigated the mechanisms of autoimmunity that arises in cancer patients treated with immunotherapies, in particular, checkpoint inhibitors.