Maria Fiammetta Romano | Prof
University of Naples Federico II

Maria Fiammetta Romano, Prof, University of Naples Federico II

I am an M.D., specialist in Oncology and Immunology, and I serve as a professor of Human Biochemistry at the School of Medicine, Federico II University of Naples, Italy. In the last decade, my research has provided significant contributions to the elucidation of the role of FK506 binding proteins (FKBP) in cancer. FKBP51 serves as a scaffold and isomerase in IKK kinase complex assembly. Its inhibition hampers the activation of NF-kappa-B transcription factors and increases sensitivity to chemo and radiotherapy in melanoma and leukemia. My research found that FKBP51 is abundantly expressed in melanoma and supports tumor growth, invasion, autophagy, and resistance to apoptosis. Its expression is correlated with the aggressiveness and metastatic potential of the tumor. FKBP51 is particularly abundant in melanoma-cancer stem cells. The cross-talk between melanoma and immune cells bidirectionally generates a spliced FKBP51 isoform that acts as a PD-L1 cochaperone and is associated with immune evasion. FKBP51s plays a role in M2 macrophage polarization and marks peripheral blood monocytes from melanoma and glioblastoma patients.

Appearances:



Festival of Biologics Day 3 @ 11:30

Combining magnetic resonance imaging with systemic monocyte phenotype for GBM management

  • Magnetic resonance imaging (MRI) is the gold standard for glioblastoma (GBM) patient evaluation. Additional non-invasive diagnostic modalities are needed
  • GBM is heavily infiltrated withtumorassociated macrophages that can be found in peripheral blood
  • FKBP51s supports alternative macrophage polarization
  • After surgery, MRI diagnosis of persistingtumorcoincides with an increase of FKBP51s+ monocytes in peripheral blood
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT

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