Jakub Tomala | Assistant Research Professor
John Hopkins University
Dr. Jakub Tomala earned his Master Science degree and Ph.D., both in Immunology, at Charles University in Prague, Czech Republic. After completing a postdoctoral fellowship at Johns Hopkins University, School of Medicine, in 2018, Dr. Tomala became senior researcher in the Laboratory of Biomolecular Recognition at Institute of Biotechnology of the Czech Academy of Sciences at BIOCEV, Czech Republic, followed by his transition in 2023 back to Johns Hopkins University, Whiting School of Engineering, as the Assistant Research Professor in Spangler Lab in the Translational Tissue Engineering Center at the School of Medicine. His focus is mainly in engineering and further studying immune molecules such as cytokines and antibodies for targeted treatment of diseases such as cancer and autoimmune disorders.
Appearances:
Festival of Biologics Day 2 @ 15:20
Engineered IL-2/antibody fusion proteins confer autoimmune disease protection through selective expansion of specific immune cell populations
- Progress in cytokine engineering is driving therapeutic translation by overcoming the limitations of these proteins as drugs
- We designed intramolecularly assembled single-agent fusion proteins (immunocytokines, ICs) which comprise of IL-2 linked to various biasing anti–IL-2 antibody that direct the cytokine towards regulatory immune cells, leading to superior autoimmune disease protection
- F5111 IC, which potently and selectively activates and expands regulatory T cells, conferring disease protection in mouse
- models of ulcerative colitis and immune checkpoint inhibitor-induced diabetes mellitus
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