Elke Prade | Scientist
Boehringer Ingelheim Pharma GmbH & Co. KG

Elke Prade, Scientist, Boehringer Ingelheim Pharma GmbH & Co. KG

Elke is currently working as a Scientist in the early stage bioprocess development department of Boehringer Ingelheim, where she focuses on downstream processing of monoclonal antibodies. A central part of her work is the optimization of purification strategies to improve product quality and to study mechanisms responsible for the removal of impurities. Elke was trained as a structural biologist as a PhD student at the Technical University of Munich and as a postdoc at the University of Michigan.

Appearances:



Festival of Biologics Day 1 @ 15:20

Cysteine in cell culture media induces acidic IgG1 species by disrupting the disulfide bond network

  • In this study, the promoting effect of cysteine on monoclonal antibody (mAb) acidic charge variants is demonstrated in in vitro and in cell culture based experiments.
  • The presence of cysteine was linked to ruptured and modified disulfide bonds, leading to enhanced levels of acidic species.
  • The data highlights cysteine in cell culture media as key player for manipulating mAb charge during the fermentation process.
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT

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