Alissa Hummer | DPhil Student
University of Oxford

Alissa Hummer, DPhil Student, University of Oxford

I am a DPhil student in Professor Charlotte Deane’s group at the University of Oxford researching and developing machine learning tools for therapeutic antibody design. Prior to my DPhil, I completed my MSci in Biochemistry at the University of Oxford and an MPhil in Biological Science at the MRC Laboratory of Molecular Biology, University of Cambridge. In my MPhil, I applied an integrative computational approach to investigate the molecular selectivity determinants governing the interaction between G protein-coupled receptors, the largest class of drug targets, and their binding partners.

Appearances:



Festival of Biologics Day 3 @ 12:10

Humanization of antibodies using a machine learning approach on large-scale repertoire data

  • Monoclonal antibody therapeutics are often produced from non-human sources and can therefore generate immunogenic responses in humans.
  • I will describe our novel, computational humanization tool, Hu-mAb, that suggests mutations to an input sequence to reduce its immunogenicity.
  • Hu-mAb is an effective replacement for trial-and-error humanization experiments, producing similar results in a fraction of the time.
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT

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