Achim Doerner | Principal Scientist
Merck KGaA

Achim Doerner, Principal Scientist, Merck KGaA

A biochemist by training, Achim has been working with bispecifics for over a decade, starting with NK cell engaging aptamers, to bispecific antibodies, bispecific ADCs balancing selectivty by avidity to technology development for their effective screening. Further interests lie in concept generation of further complex antibodies such as biparatopics or trispecifics as well as method development, currently towards microfluidics for rapid antibody hit discovery.

Appearances:



Festival of Biologics Day 2 @ 12:20

intein-mediated high throughput screening of bispecific antibodies

  • Split inteins enable reconstitution of bispecific antibodies on the protein level
  • Comparability to genetically fused bispecifics and automation are discussed
  • Broad combinatorial screening for identification of optimal bispecific antibodies
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT
last published: 17/Sep/21 16:05 GMT

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