Hybrigenics Services


For more than 20 years now, Hybrigenics is the world leading provider of services to study protein interactions (PPI) thanks to its optimized yeast two-hybrid (Y2H) technology with its patented protocol and its unique bioinformatical analysis platform. This platform validated by more than 400 publications has been extended to protein-small molecules interactions. Through our optimized version of the Chemical Yeast Three-Hybrid (CY3H), we are also a key provider of target deconvolution and drug profiling services.

Since 2016 we offer a range of services for custom antibody selection and validation. With our collaborators we have designed a fully synthetic very divers, humanized naïve Llama VHH library, based on a unique scaffold with random complementary determining regions (CDRs) established by advance molecular biology. A combination of phage display follows or not by subsequent Y2H or Yeast Display screening is applied to identify VHH nanobodies reactive to native antigens that could also retain functionality even inside living cells (so-called intrabodies). Also, large proteins, haptens and membrane receptors can be successfully selected from this library in vitro or using on cell selection (more than 100 successful projects delivered).

In addition, we take advantage of our yeast facility to develop an optimization platform very efficient and cost effective to optimize and humanize VHH selected form the Lama or antibodies.



There are two parts to the Festival of Biologics: four conferences covering Antibodies, Immunotherapy, Biosimilars and Clinical Trials and an exhibition featuring solutions for pharma and biotech.

There is a registration fee to attend the conferences. To visit the exhibition is free.