Shengya Cao | Senior Scientist
Genentech
Shengya Cao is a Sr. Scientist leading the Receptor Discovery group at Genentech. Before Genentech, Dr. Cao earned degrees in Bioengineering and Electrical Engineering from the University of Pennsylvania and performed undergraduate research in the lab of Mitchell A. Lazar studying factors regulating adipocyte differentiation. She then completed her PhD at Stanford University in the lab of Aaron F. Straight studying molecular determinants of centromeric chromatin stability and structure. At Genentech, Dr. Cao is generating new strategies that overcomes the experimental obstinance of receptor proteins to reveal undiscovered cellular crosstalk that is uniquely accessible to large-molecule interventions. The Receptor Discovery group develops and implements proteomic and cell-based technologies specifically designed to map receptor-ligand interaction networks
Appearances:
Festival of Biologics Day 2 @ 12:00
Deorphanizing Tough Membrane Targets Using Recombinant Extracellular Vesicles
Membrane proteins are major drug targets because of their central roles in regulating cellular communication. Despite this, membrane receptors remain underrepresented in interaction databases because of technical limitations. To overcome these challenges, we developed an extracellular vesicle-based method for membrane protein display that enables purification-free and high-throughput detection of receptor–ligand interactions in membranes. We demonstrate that this platform is broadly applicable and can be used to profile endogenous vesicles.
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