Liviu Movileanu | Professor, Department Of Physics
Syracuse University

Liviu Movileanu, Professor, Department Of Physics, Syracuse University

Liviu Movileanu has received his Ph.D. degree in biophysics from the University of Bucharest (1997). He has acquired postdoctoral positions at the University of Missouri (Kansas City, Missouri, 1997-1998) and the Texas A&M University Health Science Center (College Station, Texas, 1999-2004). He is now a Professor at Syracuse University, Departments of Physics, and of Biomedical and Chemical Engineering. Liviu Movileanu is also affiliated to the BioInspired Institute, Syracuse, New York. Currently, his research group is funded by the U.S. National Institutes of Health. His expertise areas include single-molecule and membrane biophysics, chemical and synthetic biology, as well as biosensors and functional biomaterials.

Appearances:



Festival of Biologics Day 3 @ 12:10

Next-Generation Ultrasensitive Sensors Using Antibody-Mimetic Protein Scaffolds

  • A new class of nanopore-sensing elements has been used for identifying individual protein biomarkers in a complex biofluid at single-molecule precision.
  • A small antibody-mimetic protein scaffold was fused to a nanometer-scale protein pore.
  • A quiet single-channel electrical current traversed the nanopore without a protein analyte.
  • Transient current blockades were noted in the presence of a protein analyte due to its reversible captures by the antibody-mimetic protein.
  • These specific protein recognition events were also unambiguously distinguished from those current transitions produced by the biofluid constituents.
  • These nanopore-sensing elements can provide the identity and quantity of various protein analytes because each produces a specific time-resolved electrical signature.
  • The outcomes of this work will impact medical biotechnology and precision medicine by providing a technological platform for protein biomarker detection.
last published: 31/Jan/23 09:55 GMT
last published: 31/Jan/23 09:55 GMT

back to speakers