James Koerber | Scientist
Genentech
JT received his PhD in Chemical Engineering from the University of California Berkeley where he developed novel protein engineering strategies for viral gene therapy. He then completed a post-doc with Jim Wells at the University of California San Francisco where he developed a novel structure-based design platform to generate phospho-specific antibodies. He currently leads a team at Genentech in the Department of Antibody Engineering focused on collaboratively discovering novel biology and transformative drugs. His group seeks to advance new therapies to patients through the development of new technologies to aid in target discovery, drug challenging targets, and overcoming drug delivery barriers.
Appearances:
Festival of Biologics Day 2 @ 17:00
Shining the light on complex membrane proteins: Antibody-based imaging agents and structural chaperones
Integral membrane proteins comprise a large untapped target space for therapeutic antibodies and often times the structure and/or function of these targets remains elusive. I will present two cases studies in which we discover, characterize, and apply VHHs and IgGs against membrane proteins. In one case study, I will detail the generation of a picomolar affinity VHH targeting human CD8 and subsequent application to image CD8+ cells in vivo. In the other case study, I will describe the discovery of an antagonist targeting a multi-component membrane complex, Nox2, which associated with autoimmune disease and new insights into the structure and function of this target.Created by
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