Cory Brooks | Associate Professor
California State University, Fresno

Cory Brooks, Associate Professor, California State University, Fresno

I obtained my Ph.D. in the field of antibody structural biology from the University of Victoria (2005-2010). My postdoctoral work was carried out at the University of Alberta (2010-2013) in the field of membrane protein structural biology.

I have been a faculty member at Fresno State since 2013. My research program is focused on using structural biology to understand the interaction of antibodies and nanobodies with their antigens. I teach a variety of biochemistry courses (CHEM 150, CHEM 155A, CHEM 3B, CHEM 240T, CHEM 156). I'm also an avid rock climber, alpinist and hiker.

Appearances:



Festival of Biologics Day 1 @ 17:10

Characterization of AR9.6: A novel MUC16 Specific mAb for Pancreatic Cancer Image Guided Surgery and Immunotherapy

  • AR9.6 is MUC16 specific antibody that shows promise as an imaging agent to assist surgical resection
  • The antibody inhibits tumor growth by reduction of oncogenic signaling mediated by ErbB receptors
  • The mAb was humanized by germline CDR grafting and retains key structural and binding characteristics as the parental murine antibody
  • An X-ray structure combined with HDX-MS revealed a conformational epitope
  • The epitope is influenced by antigen glycosylation and binding kinetics suggest avidity plays an important role in binding
last published: 31/Jan/23 09:55 GMT
last published: 31/Jan/23 09:55 GMT

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